Venous thromboembolism after hip fracture surgery in a patient with haemophilia B and factor V Arg506Gln (factor V Leiden)

R. K. Pruthi, J. A. Heit, M. M. Green, L. M. Emiliusen, W. L. Nichols, J. L. Wilke, D. A. Gastineau

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

We describe a patient with mild haemophilia B who developed symptomatic venous thromboembolism after hip arthroplasty for a traumatic fracture. A deep vein thrombosis developed in the operated leg while he was receiving a high-purity factor IX concentrate. Subsequently, he was determined to be a heterozygous carrier for the factor V Arg506Gln (Leiden) mutation. This case illustrates the importance of providing thromboprophylaxis for all patients with haemophilia receiving coagulation factor replacement and who undergo surgical procedures known to be associated with a high risk of venous thromboembolism. In patients with haemophilia and a family history of venous thromboembolism, preoperative screening for the presence of the factor V Arg506Gln mutation and other thrombophilias may be useful.

Original languageEnglish (US)
Pages (from-to)631-634
Number of pages4
JournalHaemophilia
Volume6
Issue number6
DOIs
StatePublished - Dec 21 2000

Keywords

  • Deep vein thrombosis
  • Factor V Leiden
  • Haemophilia B
  • Hip surgery

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)

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    Pruthi, R. K., Heit, J. A., Green, M. M., Emiliusen, L. M., Nichols, W. L., Wilke, J. L., & Gastineau, D. A. (2000). Venous thromboembolism after hip fracture surgery in a patient with haemophilia B and factor V Arg506Gln (factor V Leiden). Haemophilia, 6(6), 631-634. https://doi.org/10.1046/j.1365-2516.2000.00431.x