Vav proteins in cancer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The Vav family of proto-oncogenes, Vav1-3, represent a subgroup within the Dbl family of guanine nucleotide exchange factors (GEF), which are regulated by tyrosine phosphorylation and mediate the activation of Rho/Rac GTP-binding proteins downstream of numerous cell surface receptors that either have intrinsic tyrosine kinase activity or associate with nonreceptor tyrosine kinases (e.g., members of the Src family). Additionally, these Vav GEFs possess additional protein:protein interaction domains that allow them to participate in several other signaling pathways upon recruitment and activation at the plasma membrane. Recent work on Vav GEFs has demonstrated their contribution to multiple human malignancies through regulation of cell motility, survival, angiogenesis, and proliferation. In general, these effects arise from ectopic expression (Vav1), upregulation (Vav1 and Vav3), or continuous activation of Vav proteins by deregulated receptor and non-receptor tyrosine kinases (all three isoforms). This chapter will address the physiological functions of Vav proteins, their mechanism of regulation, and their emerging roles as regulators of human tumorigenesis.

Original languageEnglish (US)
Title of host publicationThe Rho GTPases in Cancer
PublisherSpringer New York
Pages77-92
Number of pages16
ISBN (Print)9781441911100
DOIs
StatePublished - 2010

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Protein-Tyrosine Kinases
Chemical activation
rac GTP-Binding Proteins
Protein Interaction Domains and Motifs
Guanine Nucleotide Exchange Factors
Neoplasms
rho GTP-Binding Proteins
Phosphorylation
Proteins
Proto-Oncogenes
Cell Surface Receptors
Cell membranes
Cell Movement
Tyrosine
Cell Survival
Protein Isoforms
Carcinogenesis
Up-Regulation
Cells
Cell Membrane

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Billadeau, D. D. (2010). Vav proteins in cancer. In The Rho GTPases in Cancer (pp. 77-92). Springer New York. https://doi.org/10.1007/978-1-4419-1111-7_5

Vav proteins in cancer. / Billadeau, Daniel D.

The Rho GTPases in Cancer. Springer New York, 2010. p. 77-92.

Research output: Chapter in Book/Report/Conference proceedingChapter

Billadeau, DD 2010, Vav proteins in cancer. in The Rho GTPases in Cancer. Springer New York, pp. 77-92. https://doi.org/10.1007/978-1-4419-1111-7_5
Billadeau DD. Vav proteins in cancer. In The Rho GTPases in Cancer. Springer New York. 2010. p. 77-92 https://doi.org/10.1007/978-1-4419-1111-7_5
Billadeau, Daniel D. / Vav proteins in cancer. The Rho GTPases in Cancer. Springer New York, 2010. pp. 77-92
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