VAV proteins as signal integrators for multi-subunit immune-recognition receptors

Martin Turner, Daniel D Billadeau

Research output: Contribution to journalArticle

235 Citations (Scopus)

Abstract

In recent years, substantial progress has been made towards the identification of intracellular signalling molecules that couple multi-subunit immune-recognition receptors (MIRRs) to their various effector functions. Among these, the VAV proteins have been observed to have a crucial role in regulating some of the earliest events in receptor signalling. VAV proteins function, in part, as guanine-nucleotide exchange factors (GEFs) for the RHO/RAC family of GTPases. This review focuses on the role of VAV proteins in the regulation of lymphocyte development and function, and emphasizes the regulatory roles that these proteins have through both GEF-dependent and -independent mechanisms.

Original languageEnglish (US)
Pages (from-to)476-486
Number of pages11
JournalNature Reviews Immunology
Volume2
Issue number7
StatePublished - Jul 2002

Fingerprint

Guanine Nucleotide Exchange Factors
Proteins
GTP Phosphohydrolases
Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

VAV proteins as signal integrators for multi-subunit immune-recognition receptors. / Turner, Martin; Billadeau, Daniel D.

In: Nature Reviews Immunology, Vol. 2, No. 7, 07.2002, p. 476-486.

Research output: Contribution to journalArticle

@article{4faff42dbdd542eb96111bb30b3b3d3f,
title = "VAV proteins as signal integrators for multi-subunit immune-recognition receptors",
abstract = "In recent years, substantial progress has been made towards the identification of intracellular signalling molecules that couple multi-subunit immune-recognition receptors (MIRRs) to their various effector functions. Among these, the VAV proteins have been observed to have a crucial role in regulating some of the earliest events in receptor signalling. VAV proteins function, in part, as guanine-nucleotide exchange factors (GEFs) for the RHO/RAC family of GTPases. This review focuses on the role of VAV proteins in the regulation of lymphocyte development and function, and emphasizes the regulatory roles that these proteins have through both GEF-dependent and -independent mechanisms.",
author = "Martin Turner and Billadeau, {Daniel D}",
year = "2002",
month = "7",
language = "English (US)",
volume = "2",
pages = "476--486",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - VAV proteins as signal integrators for multi-subunit immune-recognition receptors

AU - Turner, Martin

AU - Billadeau, Daniel D

PY - 2002/7

Y1 - 2002/7

N2 - In recent years, substantial progress has been made towards the identification of intracellular signalling molecules that couple multi-subunit immune-recognition receptors (MIRRs) to their various effector functions. Among these, the VAV proteins have been observed to have a crucial role in regulating some of the earliest events in receptor signalling. VAV proteins function, in part, as guanine-nucleotide exchange factors (GEFs) for the RHO/RAC family of GTPases. This review focuses on the role of VAV proteins in the regulation of lymphocyte development and function, and emphasizes the regulatory roles that these proteins have through both GEF-dependent and -independent mechanisms.

AB - In recent years, substantial progress has been made towards the identification of intracellular signalling molecules that couple multi-subunit immune-recognition receptors (MIRRs) to their various effector functions. Among these, the VAV proteins have been observed to have a crucial role in regulating some of the earliest events in receptor signalling. VAV proteins function, in part, as guanine-nucleotide exchange factors (GEFs) for the RHO/RAC family of GTPases. This review focuses on the role of VAV proteins in the regulation of lymphocyte development and function, and emphasizes the regulatory roles that these proteins have through both GEF-dependent and -independent mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=0036631548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036631548&partnerID=8YFLogxK

M3 - Article

VL - 2

SP - 476

EP - 486

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

IS - 7

ER -