Abstract
In recent years, substantial progress has been made towards the identification of intracellular signalling molecules that couple multi-subunit immune-recognition receptors (MIRRs) to their various effector functions. Among these, the VAV proteins have been observed to have a crucial role in regulating some of the earliest events in receptor signalling. VAV proteins function, in part, as guanine-nucleotide exchange factors (GEFs) for the RHO/RAC family of GTPases. This review focuses on the role of VAV proteins in the regulation of lymphocyte development and function, and emphasizes the regulatory roles that these proteins have through both GEF-dependent and -independent mechanisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 476-486 |
| Number of pages | 11 |
| Journal | Nature Reviews Immunology |
| Volume | 2 |
| Issue number | 7 |
| State | Published - Jul 2002 |
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ASJC Scopus subject areas
- Immunology
Cite this
VAV proteins as signal integrators for multi-subunit immune-recognition receptors. / Turner, Martin; Billadeau, Daniel D.
In: Nature Reviews Immunology, Vol. 2, No. 7, 07.2002, p. 476-486.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - VAV proteins as signal integrators for multi-subunit immune-recognition receptors
AU - Turner, Martin
AU - Billadeau, Daniel D
PY - 2002/7
Y1 - 2002/7
N2 - In recent years, substantial progress has been made towards the identification of intracellular signalling molecules that couple multi-subunit immune-recognition receptors (MIRRs) to their various effector functions. Among these, the VAV proteins have been observed to have a crucial role in regulating some of the earliest events in receptor signalling. VAV proteins function, in part, as guanine-nucleotide exchange factors (GEFs) for the RHO/RAC family of GTPases. This review focuses on the role of VAV proteins in the regulation of lymphocyte development and function, and emphasizes the regulatory roles that these proteins have through both GEF-dependent and -independent mechanisms.
AB - In recent years, substantial progress has been made towards the identification of intracellular signalling molecules that couple multi-subunit immune-recognition receptors (MIRRs) to their various effector functions. Among these, the VAV proteins have been observed to have a crucial role in regulating some of the earliest events in receptor signalling. VAV proteins function, in part, as guanine-nucleotide exchange factors (GEFs) for the RHO/RAC family of GTPases. This review focuses on the role of VAV proteins in the regulation of lymphocyte development and function, and emphasizes the regulatory roles that these proteins have through both GEF-dependent and -independent mechanisms.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036631548&partnerID=8YFLogxK
M3 - Article
VL - 2
SP - 476
EP - 486
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
SN - 1474-1733
IS - 7
ER -