VAV proteins as signal integrators for multi-subunit immune-recognition receptors

Martin Turner, Daniel D. Billadeau

Research output: Contribution to journalReview article

239 Scopus citations

Abstract

In recent years, substantial progress has been made towards the identification of intracellular signalling molecules that couple multi-subunit immune-recognition receptors (MIRRs) to their various effector functions. Among these, the VAV proteins have been observed to have a crucial role in regulating some of the earliest events in receptor signalling. VAV proteins function, in part, as guanine-nucleotide exchange factors (GEFs) for the RHO/RAC family of GTPases. This review focuses on the role of VAV proteins in the regulation of lymphocyte development and function, and emphasizes the regulatory roles that these proteins have through both GEF-dependent and -independent mechanisms.

Original languageEnglish (US)
Pages (from-to)476-486
Number of pages11
JournalNature Reviews Immunology
Volume2
Issue number7
StatePublished - Jul 1 2002

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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