TY - JOUR
T1 - Vasoreactivity to prostaglandins of rat peripheral nerve.
AU - Kihara, M.
AU - Low, P. A.
PY - 1995/4/15
Y1 - 1995/4/15
N2 - 1. We evaluated the effect of the local superfusion of prostaglandins E1, I2 and F2 alpha (PGE1, PGI2 and PGF2 alpha, respectively) on rat sciatic nerve blood flow and microvascular resistance. 2. PGE1 increased nerve blood flow (NBF) in a dose‐dependent fashion with an EC50 of 10(‐6.7) M and an asymptote of 20.1 ml (100 g)‐1 min‐1. 3. PGI2 increased NBF in a linear dose‐dependent fashion, with an EC50 of 10(‐5.1) M. PGI2 appeared to be about 1.5 orders of magnitude less potent than PGE1. 4. PGF2 alpha also increased NBF in a dose‐dependent fashion. The threshold dose appeared to be identical with PGI2 but may have a reduced capacity of response. The EC50 of 10(‐5.8) M was slightly lower than that of PGI2.
AB - 1. We evaluated the effect of the local superfusion of prostaglandins E1, I2 and F2 alpha (PGE1, PGI2 and PGF2 alpha, respectively) on rat sciatic nerve blood flow and microvascular resistance. 2. PGE1 increased nerve blood flow (NBF) in a dose‐dependent fashion with an EC50 of 10(‐6.7) M and an asymptote of 20.1 ml (100 g)‐1 min‐1. 3. PGI2 increased NBF in a linear dose‐dependent fashion, with an EC50 of 10(‐5.1) M. PGI2 appeared to be about 1.5 orders of magnitude less potent than PGE1. 4. PGF2 alpha also increased NBF in a dose‐dependent fashion. The threshold dose appeared to be identical with PGI2 but may have a reduced capacity of response. The EC50 of 10(‐5.8) M was slightly lower than that of PGI2.
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U2 - 10.1113/jphysiol.1995.sp020678
DO - 10.1113/jphysiol.1995.sp020678
M3 - Article
C2 - 7602538
AN - SCOPUS:0028929342
SN - 0022-3751
VL - 484
SP - 463
EP - 467
JO - The Journal of Physiology
JF - The Journal of Physiology
IS - 2
ER -