Vasoreactivity to prostaglandins of rat peripheral nerve

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Abstract

1. We evaluated the effect of the local superfusion of prostaglandins E1, I2 and F(2α) (PGE1, PGI2 and PGF(2α), respectively) on rat sciatic nerve blood flow and microvascular resistance. 2. PGE1 increased nerve blood flow (NBF) in a dose-dependent fashion with an EC50 of 10-6.7 M and an asymptote of 20.1 ml (100 g)-1 min-1. 3. PGI2 increased NBF in a linear dose-dependent fashion, with an EC50 of 10-5.1 M. PGI2 appeared to be about 1.5 orders of magnitude less potent than PGE1. 4. PGF(2α) also increased NBF in a dose-dependent fashion. The threshold dose appeared to be identical with PGI2 but may have a reduced capacity of response. The EC50 of 10-5.8 M was slightly lower than that of PGI2.

Original languageEnglish (US)
Pages (from-to)463-467
Number of pages5
JournalJournal of Physiology
Volume484
Issue number2
StatePublished - 1995

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Epoprostenol
Peripheral Nerves
Alprostadil
Prostaglandins
Prostaglandins F
Sciatic Nerve

ASJC Scopus subject areas

  • Physiology

Cite this

Vasoreactivity to prostaglandins of rat peripheral nerve. / Kihara, M.; Low, Phillip Anson.

In: Journal of Physiology, Vol. 484, No. 2, 1995, p. 463-467.

Research output: Contribution to journalArticle

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