Abstract
This study reports the cardiovascular and renal actions of a novel and newly synthesized 27-amino acid peptide termed vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related to ANP. VNP also possesses the five-amino acid COOH terminus of ANP. The current study demonstrates both in vitro and in vivo that VNP possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2048-2052 |
| Number of pages | 5 |
| Journal | Journal of Clinical Investigation |
| Volume | 92 |
| Issue number | 4 |
| State | Published - 1993 |
Fingerprint
Keywords
- Cardiorenal function
- Cgmp
- Endothelium
- Natriuretic peptide
- Vasorelaxation
ASJC Scopus subject areas
- Medicine(all)
Cite this
Vasonatrin peptide : A unique synthetic natriuretic and vasorelaxing peptide. / Wei, Chi Ming; Kim, Cheol H.; Miller, Virginia M; Burnett, John C Jr.
In: Journal of Clinical Investigation, Vol. 92, No. 4, 1993, p. 2048-2052.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vasonatrin peptide
T2 - A unique synthetic natriuretic and vasorelaxing peptide
AU - Wei, Chi Ming
AU - Kim, Cheol H.
AU - Miller, Virginia M
AU - Burnett, John C Jr.
PY - 1993
Y1 - 1993
N2 - This study reports the cardiovascular and renal actions of a novel and newly synthesized 27-amino acid peptide termed vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related to ANP. VNP also possesses the five-amino acid COOH terminus of ANP. The current study demonstrates both in vitro and in vivo that VNP possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP.
AB - This study reports the cardiovascular and renal actions of a novel and newly synthesized 27-amino acid peptide termed vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related to ANP. VNP also possesses the five-amino acid COOH terminus of ANP. The current study demonstrates both in vitro and in vivo that VNP possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP.
KW - Cardiorenal function
KW - Cgmp
KW - Endothelium
KW - Natriuretic peptide
KW - Vasorelaxation
UR - http://www.scopus.com/inward/record.url?scp=0027448795&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027448795&partnerID=8YFLogxK
M3 - Article
C2 - 8408658
AN - SCOPUS:0027448795
VL - 92
SP - 2048
EP - 2052
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
SN - 0021-9738
IS - 4
ER -