Vasonatrin peptide: A unique synthetic natriuretic and vasorelaxing peptide

Chi Ming Wei; Cheol H. Kim; Virginia M. Miller; John C. Burnett

doi:10.1172/JCI116800

Vasonatrin peptide: A unique synthetic natriuretic and vasorelaxing peptide

Chi Ming Wei, Cheol H. Kim, Virginia M. Miller, John C. Burnett

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

This study reports the cardiovascular and renal actions of a novel and newly synthesized 27-amino acid peptide termed vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related to ANP. VNP also possesses the five-amino acid COOH terminus of ANP. The current study demonstrates both in vitro and in vivo that VNP possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP.

Original language	English (US)
Pages (from-to)	2048-2052
Number of pages	5
Journal	Journal of Clinical Investigation
Volume	92
Issue number	4
DOIs	https://doi.org/10.1172/JCI116800
State	Published - 1993

Keywords

Cardiorenal function
Cgmp
Endothelium
Natriuretic peptide
Vasorelaxation

ASJC Scopus subject areas

Medicine(all)

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10.1172/JCI116800

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title = "Vasonatrin peptide: A unique synthetic natriuretic and vasorelaxing peptide",

abstract = "This study reports the cardiovascular and renal actions of a novel and newly synthesized 27-amino acid peptide termed vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related to ANP. VNP also possesses the five-amino acid COOH terminus of ANP. The current study demonstrates both in vitro and in vivo that VNP possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP.",

keywords = "Cardiorenal function, Cgmp, Endothelium, Natriuretic peptide, Vasorelaxation",

author = "Wei, {Chi Ming} and Kim, {Cheol H.} and Miller, {Virginia M.} and Burnett, {John C.}",

year = "1993",

doi = "10.1172/JCI116800",

language = "English (US)",

volume = "92",

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issn = "0021-9738",

publisher = "The American Society for Clinical Investigation",

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T1 - Vasonatrin peptide

T2 - A unique synthetic natriuretic and vasorelaxing peptide

AU - Wei, Chi Ming

AU - Kim, Cheol H.

AU - Miller, Virginia M.

AU - Burnett, John C.

PY - 1993

Y1 - 1993

N2 - This study reports the cardiovascular and renal actions of a novel and newly synthesized 27-amino acid peptide termed vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related to ANP. VNP also possesses the five-amino acid COOH terminus of ANP. The current study demonstrates both in vitro and in vivo that VNP possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP.

AB - This study reports the cardiovascular and renal actions of a novel and newly synthesized 27-amino acid peptide termed vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related to ANP. VNP also possesses the five-amino acid COOH terminus of ANP. The current study demonstrates both in vitro and in vivo that VNP possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP.

KW - Cardiorenal function

KW - Cgmp

KW - Endothelium

KW - Natriuretic peptide

KW - Vasorelaxation

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Vasonatrin peptide: A unique synthetic natriuretic and vasorelaxing peptide

Abstract

Keywords

ASJC Scopus subject areas

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