Vasonatrin peptide: A unique synthetic natriuretic and vasorelaxing peptide

Chi Ming Wei; Cheol H. Kim; Virginia M. Miller; John C. Burnett

doi:10.1172/JCI116800

Vasonatrin peptide: A unique synthetic natriuretic and vasorelaxing peptide

Chi Ming Wei, Cheol H. Kim, Virginia M. Miller, John C. Burnett

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

This study reports the cardiovascular and renal actions of a novel and newly synthesized 27-amino acid peptide termed vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related to ANP. VNP also possesses the five-amino acid COOH terminus of ANP. The current study demonstrates both in vitro and in vivo that VNP possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP.

Original language	English (US)
Pages (from-to)	2048-2052
Number of pages	5
Journal	Journal of Clinical Investigation
Volume	92
Issue number	4
DOIs	https://doi.org/10.1172/JCI116800
State	Published - 1993

Keywords

Cardiorenal function
Cgmp
Endothelium
Natriuretic peptide
Vasorelaxation

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1172/JCI116800

Fingerprint Dive into the research topics of 'Vasonatrin peptide: A unique synthetic natriuretic and vasorelaxing peptide'. Together they form a unique fingerprint.

Cite this

@article{bb76dbdbe0364bd1a05379812b6d697e,

title = "Vasonatrin peptide: A unique synthetic natriuretic and vasorelaxing peptide",

abstract = "This study reports the cardiovascular and renal actions of a novel and newly synthesized 27-amino acid peptide termed vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related to ANP. VNP also possesses the five-amino acid COOH terminus of ANP. The current study demonstrates both in vitro and in vivo that VNP possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP.",

keywords = "Cardiorenal function, Cgmp, Endothelium, Natriuretic peptide, Vasorelaxation",

author = "Wei, {Chi Ming} and Kim, {Cheol H.} and Miller, {Virginia M.} and Burnett, {John C.}",

year = "1993",

doi = "10.1172/JCI116800",

language = "English (US)",

volume = "92",

pages = "2048--2052",

journal = "Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "The American Society for Clinical Investigation",

number = "4",

}

TY - JOUR

T1 - Vasonatrin peptide

T2 - A unique synthetic natriuretic and vasorelaxing peptide

AU - Wei, Chi Ming

AU - Kim, Cheol H.

AU - Miller, Virginia M.

AU - Burnett, John C.

PY - 1993

Y1 - 1993

N2 - This study reports the cardiovascular and renal actions of a novel and newly synthesized 27-amino acid peptide termed vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related to ANP. VNP also possesses the five-amino acid COOH terminus of ANP. The current study demonstrates both in vitro and in vivo that VNP possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP.

AB - This study reports the cardiovascular and renal actions of a novel and newly synthesized 27-amino acid peptide termed vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related to ANP. VNP also possesses the five-amino acid COOH terminus of ANP. The current study demonstrates both in vitro and in vivo that VNP possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP.

KW - Cardiorenal function

KW - Cgmp

KW - Endothelium

KW - Natriuretic peptide

KW - Vasorelaxation

UR - http://www.scopus.com/inward/record.url?scp=0027448795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027448795&partnerID=8YFLogxK

U2 - 10.1172/JCI116800

DO - 10.1172/JCI116800

M3 - Article

C2 - 8408658

AN - SCOPUS:0027448795

VL - 92

SP - 2048

EP - 2052

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 4

ER -

Vasonatrin peptide: A unique synthetic natriuretic and vasorelaxing peptide

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this