Vasonatrin peptide: A unique synthetic natriuretic and vasorelaxing peptide

Chi Ming Wei, Cheol H. Kim, Virginia M. Miller, John C. Burnett

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

This study reports the cardiovascular and renal actions of a novel and newly synthesized 27-amino acid peptide termed vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). This synthetic peptide possesses the 22-amino acid structure of CNP, which is a cardiovascular selective peptide of endothelial origin and is structurally related to ANP. VNP also possesses the five-amino acid COOH terminus of ANP. The current study demonstrates both in vitro and in vivo that VNP possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP.

Original languageEnglish (US)
Pages (from-to)2048-2052
Number of pages5
JournalJournal of Clinical Investigation
Volume92
Issue number4
DOIs
StatePublished - 1993

Keywords

  • Cardiorenal function
  • Cgmp
  • Endothelium
  • Natriuretic peptide
  • Vasorelaxation

ASJC Scopus subject areas

  • Medicine(all)

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