Vasomotor rhinitis update

Devyani Lal, Jacquelynne P. Corey

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Purpose of review: This review was conducted to examine new data on vasomotor rhinitis, a common clinical problem. Recent findings: Recent publications highlight advances in the study of the pathophysiology of vasomotor rhinitis. Electron microscopic and ultracytochemical evaluation of the nasal mucosa in vasomotor rhinitis demonstrates an emerging role of neuropeptides and nitric oxide in the pathogenesis of vasomotor rhinitis. Ozone, cigarette smoke, and other environmental factors may trigger neurogenic mechanisms that lead to vasomotor rhinitis. Objective tests have documented the presence of hypoactive sympathetic autonomic dysfunction. Such assessments also suggest autonomic dysfunction as a possible link between vasomotor rhinitis and gastroesophageal reflux disease. Recent publications propose nasal secretory protein analysis as a possible diagnostic tool. Evidence-based review of treatment outcomes shows topical sprays of azelastine, budesonide, and ipratropium to be of benefit in vasomotor rhinitis. Summary: A better understanding of the role of nitric oxide and neuropeptides in the pathogenesis of vasomotor rhinitis has opened new avenues in research, diagnosis, and management. Clinical diagnosis may be aided by the analysis of nasal secretory proteins. Effective treatments include antihistamine, anticholinergics, and steroid nasal sprays.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Issue number3
StatePublished - Jun 2004


  • Allergic rhinitis
  • Chronic rhinitis
  • Nitric oxide
  • Nonallergic rhinitis
  • Nonallergic rhinitis with eosinophilia
  • Vasomotor rhinitis

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


Dive into the research topics of 'Vasomotor rhinitis update'. Together they form a unique fingerprint.

Cite this