Vasculitis on brain angiography is not always vasculitis: Intravascular large B-cell lymphoma mimicking central nervous system vasculitis

Corbin Rayfield, Lester Mertz, Katalin Kelemen, Fawad Aslam

Research output: Contribution to journalArticle


A 68-year-old man, with a history of non-Hodgkin's lymphoma in remission, was admitted for homonymous hemianopsia, headaches and subacute progressive cognitive decline. Imaging revealed brain infarcts and angiography suggested vasculitis. A brain biopsy, however, revealed an intravascular large B-cell lymphoma (IVLBL). Central nervous system (CNS) vasculitis and IVLBL of the brain are extremely rare diseases that can have an almost identical clinical presentation. Angiographic findings are very similar but usually are reported as compatible with vasculitis. Brain biopsy or a random skin biopsy are crucial in diagnosing IVLBL as the accuracy of angiographic findings for CNS vasculitis is low.

Original languageEnglish (US)
Article numbere230753
JournalBMJ case reports
Issue number8
StatePublished - Aug 1 2019



  • CNS cancer
  • neuroimaging
  • neurology
  • neurooncology
  • vasculitis

ASJC Scopus subject areas

  • Medicine(all)

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