Vasculitic neuropathies

Kelly Graham Gwathmey, Ted Michael Burns, Michael Paul Collins, P. James Bonham Dyck

Research output: Contribution to journalReview article

79 Scopus citations

Abstract

The vasculitic neuropathies are a diverse group of disorders characterised by the acute-to-subacute onset of painful sensory and motor deficits that result from inflammatory destruction of nerve blood vessels and subsequent ischaemic injury. They are common in patients with primary systemic vasculitis and are seen in vasculitis secondary to disorders such as rheumatoid arthritis, viral infections, and diabetic inflammatory neuropathies. It is imperative that neurologists recognise these disorders to initiate treatment promptly and thereby prevent morbidity and mortality. To simplify the approach to patients with vasculitis of the peripheral nerves, a straightforward, dichotomous classification scheme can be used in which the vasculitic neuropathies are divided into two groups-nerve large arteriole vasculitis and nerve microvasculitis-on the basis of the size of the involved vessels. The size of the affected blood vessels correlates with the clinical course and prognosis in patients with vasculitic neuropathy.

Original languageEnglish (US)
Pages (from-to)67-82
Number of pages16
JournalThe Lancet Neurology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Clinical Neurology

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    Gwathmey, K. G., Burns, T. M., Collins, M. P., & Dyck, P. J. B. (2014). Vasculitic neuropathies. The Lancet Neurology, 13(1), 67-82. https://doi.org/10.1016/S1474-4422(13)70236-9