Vasculature and kidney complications in sickle cell disease

Research output: Contribution to journalShort survey

48 Scopus citations

Abstract

Recent developments in sickle cell disease include the concept of a vasculopathic state and the classification of sickle cell disease into a hemolysis-endothelial dysfunction phenotype or a viscosity-vasoocclusion phenotype. The hemolysis-endothelial dysfunction phenotype largely reflects deficiency of or resistance to nitric oxide. In addition to discussing these areas, we suggest that the hemolysis-endothelial dysfunction phenotype also reflects the instability of sickle hemoglobin, the release of heme, and the induction of heme oxygenase-1. From these perspectives the renal complications of sickle cell disease are discussed and classified.

Original languageEnglish (US)
Pages (from-to)781-784
Number of pages4
JournalJournal of the American Society of Nephrology
Volume23
Issue number5
DOIs
StatePublished - May 1 2012

ASJC Scopus subject areas

  • Nephrology

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