TY - JOUR
T1 - Vascularized composite allotransplant in the realm of regenerative plastic surgery
AU - Chim, Harvey
AU - Amer, Hatem
AU - Mardini, Samir
AU - Moran, Steven L.
PY - 2014/7
Y1 - 2014/7
N2 - Vascularized composite allotransplant (VCA) has led to new treatment options for patients with severe upper extremity and facial injuries. Although VCA can restore form and function, it exposes the patient to the risks associated with lifelong immunosuppression. Hopefully, ongoing advances in regenerative medicine will someday obviate the need for VCA, but until that time, VCA remains an immediate means of reconstructing otherwise unreconstructable defects. We review the outcomes of hand and face transplants, as well as the recent developments in immunosuppression as it relates to the field of VCA.
AB - Vascularized composite allotransplant (VCA) has led to new treatment options for patients with severe upper extremity and facial injuries. Although VCA can restore form and function, it exposes the patient to the risks associated with lifelong immunosuppression. Hopefully, ongoing advances in regenerative medicine will someday obviate the need for VCA, but until that time, VCA remains an immediate means of reconstructing otherwise unreconstructable defects. We review the outcomes of hand and face transplants, as well as the recent developments in immunosuppression as it relates to the field of VCA.
UR - http://www.scopus.com/inward/record.url?scp=84904609104&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904609104&partnerID=8YFLogxK
U2 - 10.1016/j.mayocp.2014.05.009
DO - 10.1016/j.mayocp.2014.05.009
M3 - Article
C2 - 24996237
AN - SCOPUS:84904609104
SN - 0025-6196
VL - 89
SP - 1009
EP - 1020
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 7
ER -