Vascularized Bone Allotransplantation: Current State and Implications for Future Reconstructive Surgery

Allen Thorp Bishop, Michael Pelzer

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Segmental bone defects resulting from traumatic loss, osteomyelitis, and osteolysis after arthroplasty and limb-sparing tumor surgery are encountered commonly in orthopedic practice. Allograft bone, matched to fit the defect and secured with internal fixation, is used frequently for the reconstruction of these difficult problems. Late stress fracture, infection, and non-unions are frequent complications when nonviable bone is used. Living autogenous bone, whose circulation in maintained by microvascular repair, can adapt to stress and heals much more readily. Living autografts have limited reconstructive potential, however, because of the size, shape, and strength of available donor sites. A living allograft transplant would combine the best characteristics of allograft and living autograft reconstruction. Current research is focused on overcoming the potentially serious problems associated with immunosuppressive treatments. The use of surgical angiogenesis combined with short-term immunosuppression may maintain viability of a vascularized bone allograft without need for long-term immunosuppression or induction of tolerance.

Original languageEnglish (US)
Pages (from-to)109-122
Number of pages14
JournalOrthopedic Clinics of North America
Volume38
Issue number1
DOIs
StatePublished - Jan 2007

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Reconstructive Surgical Procedures
Allografts
Bone and Bones
Autografts
Immunosuppression
Stress Fractures
Osteolysis
Osteomyelitis
Immunosuppressive Agents
Arthroplasty
Orthopedics
Extremities
Transplants
Infection
Research
Neoplasms

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Vascularized Bone Allotransplantation : Current State and Implications for Future Reconstructive Surgery. / Bishop, Allen Thorp; Pelzer, Michael.

In: Orthopedic Clinics of North America, Vol. 38, No. 1, 01.2007, p. 109-122.

Research output: Contribution to journalArticle

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