Vascular wall elasticity measurement by magnetic resonance imaging

David A Woodrum, A. J. Romano, Amir Lerman, U. H. Pandya, D. Brosh, P. J. Rossman, Lilach O Lerman, Richard Lorne Ehman

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The goal of this current study was to determine whether an MRI-based elastography (MRE) method can visualize and assess propagating mechanical waves within fluid-filled vessels and to investigate the feasibility of measuring the elastic properties of vessel walls and quantitatively assessing stenotic lesions by using MRE. The ability to measure the Young's modulus-wall thickness product was tested using a thin-walled latex vessel model. Also tested in vessel models was the ability to quantitate the degree of stenosis by measuring transmitted and reflected mechanical waves. This method was then applied to ex vivo porcine models and in vivo human arteries to further test its feasibility. The results provide preliminary evidence that MRE can be used to quantitatively assess the stiffness of blood vessels, and provide a non-morphologic method to measure stenosis. With further development, it is possible that the method can be implemented in vivo.

Original languageEnglish (US)
Pages (from-to)593-600
Number of pages8
JournalMagnetic Resonance in Medicine
Volume56
Issue number3
DOIs
StatePublished - Sep 2006

Fingerprint

Elasticity
Elasticity Imaging Techniques
Blood Vessels
Magnetic Resonance Imaging
Pathologic Constriction
Elastic Modulus
Latex
Swine
Arteries

Keywords

  • Arterial elasticity
  • Arteries
  • Blood vessel
  • Hypertension
  • MR elastography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Vascular wall elasticity measurement by magnetic resonance imaging. / Woodrum, David A; Romano, A. J.; Lerman, Amir; Pandya, U. H.; Brosh, D.; Rossman, P. J.; Lerman, Lilach O; Ehman, Richard Lorne.

In: Magnetic Resonance in Medicine, Vol. 56, No. 3, 09.2006, p. 593-600.

Research output: Contribution to journalArticle

@article{b0f69ecff9a245d4b87ec2f82ba1ef9e,
title = "Vascular wall elasticity measurement by magnetic resonance imaging",
abstract = "The goal of this current study was to determine whether an MRI-based elastography (MRE) method can visualize and assess propagating mechanical waves within fluid-filled vessels and to investigate the feasibility of measuring the elastic properties of vessel walls and quantitatively assessing stenotic lesions by using MRE. The ability to measure the Young's modulus-wall thickness product was tested using a thin-walled latex vessel model. Also tested in vessel models was the ability to quantitate the degree of stenosis by measuring transmitted and reflected mechanical waves. This method was then applied to ex vivo porcine models and in vivo human arteries to further test its feasibility. The results provide preliminary evidence that MRE can be used to quantitatively assess the stiffness of blood vessels, and provide a non-morphologic method to measure stenosis. With further development, it is possible that the method can be implemented in vivo.",
keywords = "Arterial elasticity, Arteries, Blood vessel, Hypertension, MR elastography",
author = "Woodrum, {David A} and Romano, {A. J.} and Amir Lerman and Pandya, {U. H.} and D. Brosh and Rossman, {P. J.} and Lerman, {Lilach O} and Ehman, {Richard Lorne}",
year = "2006",
month = "9",
doi = "10.1002/mrm.20991",
language = "English (US)",
volume = "56",
pages = "593--600",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Vascular wall elasticity measurement by magnetic resonance imaging

AU - Woodrum, David A

AU - Romano, A. J.

AU - Lerman, Amir

AU - Pandya, U. H.

AU - Brosh, D.

AU - Rossman, P. J.

AU - Lerman, Lilach O

AU - Ehman, Richard Lorne

PY - 2006/9

Y1 - 2006/9

N2 - The goal of this current study was to determine whether an MRI-based elastography (MRE) method can visualize and assess propagating mechanical waves within fluid-filled vessels and to investigate the feasibility of measuring the elastic properties of vessel walls and quantitatively assessing stenotic lesions by using MRE. The ability to measure the Young's modulus-wall thickness product was tested using a thin-walled latex vessel model. Also tested in vessel models was the ability to quantitate the degree of stenosis by measuring transmitted and reflected mechanical waves. This method was then applied to ex vivo porcine models and in vivo human arteries to further test its feasibility. The results provide preliminary evidence that MRE can be used to quantitatively assess the stiffness of blood vessels, and provide a non-morphologic method to measure stenosis. With further development, it is possible that the method can be implemented in vivo.

AB - The goal of this current study was to determine whether an MRI-based elastography (MRE) method can visualize and assess propagating mechanical waves within fluid-filled vessels and to investigate the feasibility of measuring the elastic properties of vessel walls and quantitatively assessing stenotic lesions by using MRE. The ability to measure the Young's modulus-wall thickness product was tested using a thin-walled latex vessel model. Also tested in vessel models was the ability to quantitate the degree of stenosis by measuring transmitted and reflected mechanical waves. This method was then applied to ex vivo porcine models and in vivo human arteries to further test its feasibility. The results provide preliminary evidence that MRE can be used to quantitatively assess the stiffness of blood vessels, and provide a non-morphologic method to measure stenosis. With further development, it is possible that the method can be implemented in vivo.

KW - Arterial elasticity

KW - Arteries

KW - Blood vessel

KW - Hypertension

KW - MR elastography

UR - http://www.scopus.com/inward/record.url?scp=33748338132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748338132&partnerID=8YFLogxK

U2 - 10.1002/mrm.20991

DO - 10.1002/mrm.20991

M3 - Article

VL - 56

SP - 593

EP - 600

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 3

ER -