Vascular wall elasticity measurement by magnetic resonance imaging

D. A. Woodrum, A. J. Romano, A. Lerman, U. H. Pandya, D. Brosh, P. J. Rossman, L. O. Lerman, R. L. Ehman

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

The goal of this current study was to determine whether an MRI-based elastography (MRE) method can visualize and assess propagating mechanical waves within fluid-filled vessels and to investigate the feasibility of measuring the elastic properties of vessel walls and quantitatively assessing stenotic lesions by using MRE. The ability to measure the Young's modulus-wall thickness product was tested using a thin-walled latex vessel model. Also tested in vessel models was the ability to quantitate the degree of stenosis by measuring transmitted and reflected mechanical waves. This method was then applied to ex vivo porcine models and in vivo human arteries to further test its feasibility. The results provide preliminary evidence that MRE can be used to quantitatively assess the stiffness of blood vessels, and provide a non-morphologic method to measure stenosis. With further development, it is possible that the method can be implemented in vivo.

Original languageEnglish (US)
Pages (from-to)593-600
Number of pages8
JournalMagnetic Resonance in Medicine
Volume56
Issue number3
DOIs
StatePublished - Sep 1 2006

Keywords

  • Arterial elasticity
  • Arteries
  • Blood vessel
  • Hypertension
  • MR elastography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Vascular wall elasticity measurement by magnetic resonance imaging'. Together they form a unique fingerprint.

  • Cite this