Vascular tumors in infants: Case report and review of clinical, histopathologic, and immunohistochemical characteristics of infantile hemangioma, pyogenic granuloma, noninvoluting congenital hemangioma, tufted angioma, and kaposiform hemangioendothelioma

Emma F. Johnson, Dawn M. Davis, Megha M Tollefson, Karen Fritchie, Lawrence E. Gibson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Vascular tumors in infants present a diagnostic and treatment dilemma for both clinicians and pathologists. Infantile hemangioma, the most common vascular tumor in infants, can be confused for other less common vascular tumors in infants. Correct and timely diagnosis is important, as some vascular tumors can be associated with life-threatening coagulopathy. We present the cases of 5 vascular tumors that have clinical and histologic overlap: infantile hemangioma, pyogenic granuloma, noninvoluting congenital hemangioma, tufted angioma, and kaposiform hemangioendothelioma. Typical clinical and histopathologic features of each lesion are summarized. We review the utility and characteristic immunohistochemistry including CD31, CD34, GLUT-1, D2-40, LYVE-1, Prox-1, and WT-1. Collaboration between the clinician and the dermatopathologist correlating the clinical history and histopathologic features can lead to the correct diagnosis, whereas the utility of immunohistochemistry remains in question.

Original languageEnglish (US)
Pages (from-to)231-239
Number of pages9
JournalAmerican Journal of Dermatopathology
Volume40
Issue number4
DOIs
StatePublished - Apr 1 2018

Fingerprint

Pyogenic Granuloma
Hemangioma
Blood Vessels
Neoplasms
Immunohistochemistry
Naproxen
Tufted angioma
Kaposiform Hemangioendothelioma

Keywords

  • Immunohistochemistry
  • Infantile hemangioma
  • Kaposiform hemangioendothelioma
  • Pediatrics
  • Pyogenic granuloma
  • Tufted angioma
  • Vascular tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

Cite this

@article{0e41f3fb7a0a404faec4da393ee18ee3,
title = "Vascular tumors in infants: Case report and review of clinical, histopathologic, and immunohistochemical characteristics of infantile hemangioma, pyogenic granuloma, noninvoluting congenital hemangioma, tufted angioma, and kaposiform hemangioendothelioma",
abstract = "Vascular tumors in infants present a diagnostic and treatment dilemma for both clinicians and pathologists. Infantile hemangioma, the most common vascular tumor in infants, can be confused for other less common vascular tumors in infants. Correct and timely diagnosis is important, as some vascular tumors can be associated with life-threatening coagulopathy. We present the cases of 5 vascular tumors that have clinical and histologic overlap: infantile hemangioma, pyogenic granuloma, noninvoluting congenital hemangioma, tufted angioma, and kaposiform hemangioendothelioma. Typical clinical and histopathologic features of each lesion are summarized. We review the utility and characteristic immunohistochemistry including CD31, CD34, GLUT-1, D2-40, LYVE-1, Prox-1, and WT-1. Collaboration between the clinician and the dermatopathologist correlating the clinical history and histopathologic features can lead to the correct diagnosis, whereas the utility of immunohistochemistry remains in question.",
keywords = "Immunohistochemistry, Infantile hemangioma, Kaposiform hemangioendothelioma, Pediatrics, Pyogenic granuloma, Tufted angioma, Vascular tumors",
author = "Johnson, {Emma F.} and Davis, {Dawn M.} and Tollefson, {Megha M} and Karen Fritchie and Gibson, {Lawrence E.}",
year = "2018",
month = "4",
day = "1",
doi = "10.1097/DAD.0000000000000983",
language = "English (US)",
volume = "40",
pages = "231--239",
journal = "American Journal of Dermatopathology",
issn = "0193-1091",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Vascular tumors in infants

T2 - Case report and review of clinical, histopathologic, and immunohistochemical characteristics of infantile hemangioma, pyogenic granuloma, noninvoluting congenital hemangioma, tufted angioma, and kaposiform hemangioendothelioma

AU - Johnson, Emma F.

AU - Davis, Dawn M.

AU - Tollefson, Megha M

AU - Fritchie, Karen

AU - Gibson, Lawrence E.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Vascular tumors in infants present a diagnostic and treatment dilemma for both clinicians and pathologists. Infantile hemangioma, the most common vascular tumor in infants, can be confused for other less common vascular tumors in infants. Correct and timely diagnosis is important, as some vascular tumors can be associated with life-threatening coagulopathy. We present the cases of 5 vascular tumors that have clinical and histologic overlap: infantile hemangioma, pyogenic granuloma, noninvoluting congenital hemangioma, tufted angioma, and kaposiform hemangioendothelioma. Typical clinical and histopathologic features of each lesion are summarized. We review the utility and characteristic immunohistochemistry including CD31, CD34, GLUT-1, D2-40, LYVE-1, Prox-1, and WT-1. Collaboration between the clinician and the dermatopathologist correlating the clinical history and histopathologic features can lead to the correct diagnosis, whereas the utility of immunohistochemistry remains in question.

AB - Vascular tumors in infants present a diagnostic and treatment dilemma for both clinicians and pathologists. Infantile hemangioma, the most common vascular tumor in infants, can be confused for other less common vascular tumors in infants. Correct and timely diagnosis is important, as some vascular tumors can be associated with life-threatening coagulopathy. We present the cases of 5 vascular tumors that have clinical and histologic overlap: infantile hemangioma, pyogenic granuloma, noninvoluting congenital hemangioma, tufted angioma, and kaposiform hemangioendothelioma. Typical clinical and histopathologic features of each lesion are summarized. We review the utility and characteristic immunohistochemistry including CD31, CD34, GLUT-1, D2-40, LYVE-1, Prox-1, and WT-1. Collaboration between the clinician and the dermatopathologist correlating the clinical history and histopathologic features can lead to the correct diagnosis, whereas the utility of immunohistochemistry remains in question.

KW - Immunohistochemistry

KW - Infantile hemangioma

KW - Kaposiform hemangioendothelioma

KW - Pediatrics

KW - Pyogenic granuloma

KW - Tufted angioma

KW - Vascular tumors

UR - http://www.scopus.com/inward/record.url?scp=85052567317&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052567317&partnerID=8YFLogxK

U2 - 10.1097/DAD.0000000000000983

DO - 10.1097/DAD.0000000000000983

M3 - Article

C2 - 29561329

AN - SCOPUS:85052567317

VL - 40

SP - 231

EP - 239

JO - American Journal of Dermatopathology

JF - American Journal of Dermatopathology

SN - 0193-1091

IS - 4

ER -