Vascular targeting in photodynamic occlusion of subretinal vessels

U. Schmidt-Erfurth, T. Hasan, E. Gragoudas, N. Michaud, Thomas J Flotte, R. Birngruber

Research output: Contribution to journalArticle

204 Citations (Scopus)

Abstract

Purpose: To evaluate the potential of photodynamic therapy (PDT) using benzoporphyrin derivative (BPD) for occlusion of subretinal neovascular membranes, the authors studied efficiency and collateral damage of PDT- induced photothrombosis in the rabbit choriocapillary layer. Method: Benzoporphyrin derivative, a new photosensitizer, currently in clinical trials for tumor therapy, was used. Low-density lipoprotein served as a carrier to enhance selective targeting of vascular endothelial cells. Results: Complete choriocapillary occlusion was achieved at a BPD dose of 2 mg/ kg and a radiant exposure as low as 10 J/cm2. When PDT was performed 3 hours after BPD application, damage to the neural retina was minimal. Only inner photoreceptor segments showed mitochondrial swelling probably secondary to choroidal ischemia. Bruch's membrane remained intact. Retinal pigment epithelium was invariably damaged as seen with other photosensitizers. Conclusion: Compared with photocoagulation BPD-PDT allows endothelial-bound intraluminal photothrombosis, sparing important structures such as neural retina and Bruch's membrane. It may thus provide a more selective treatment of juxtafoveal and subfoveal neovascular membranes.

Original languageEnglish (US)
Pages (from-to)1953-1961
Number of pages9
JournalOphthalmology
Volume101
Issue number12
StatePublished - 1994
Externally publishedYes

Fingerprint

Photochemotherapy
Blood Vessels
Bruch Membrane
Photosensitizing Agents
Retina
Mitochondrial Swelling
Membranes
Retinal Pigment Epithelium
Light Coagulation
LDL Lipoproteins
Ischemia
Endothelial Cells
Clinical Trials
Rabbits
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Schmidt-Erfurth, U., Hasan, T., Gragoudas, E., Michaud, N., Flotte, T. J., & Birngruber, R. (1994). Vascular targeting in photodynamic occlusion of subretinal vessels. Ophthalmology, 101(12), 1953-1961.

Vascular targeting in photodynamic occlusion of subretinal vessels. / Schmidt-Erfurth, U.; Hasan, T.; Gragoudas, E.; Michaud, N.; Flotte, Thomas J; Birngruber, R.

In: Ophthalmology, Vol. 101, No. 12, 1994, p. 1953-1961.

Research output: Contribution to journalArticle

Schmidt-Erfurth, U, Hasan, T, Gragoudas, E, Michaud, N, Flotte, TJ & Birngruber, R 1994, 'Vascular targeting in photodynamic occlusion of subretinal vessels', Ophthalmology, vol. 101, no. 12, pp. 1953-1961.
Schmidt-Erfurth U, Hasan T, Gragoudas E, Michaud N, Flotte TJ, Birngruber R. Vascular targeting in photodynamic occlusion of subretinal vessels. Ophthalmology. 1994;101(12):1953-1961.
Schmidt-Erfurth, U. ; Hasan, T. ; Gragoudas, E. ; Michaud, N. ; Flotte, Thomas J ; Birngruber, R. / Vascular targeting in photodynamic occlusion of subretinal vessels. In: Ophthalmology. 1994 ; Vol. 101, No. 12. pp. 1953-1961.
@article{44febcb0b0854b1cb3402f806cb3afe5,
title = "Vascular targeting in photodynamic occlusion of subretinal vessels",
abstract = "Purpose: To evaluate the potential of photodynamic therapy (PDT) using benzoporphyrin derivative (BPD) for occlusion of subretinal neovascular membranes, the authors studied efficiency and collateral damage of PDT- induced photothrombosis in the rabbit choriocapillary layer. Method: Benzoporphyrin derivative, a new photosensitizer, currently in clinical trials for tumor therapy, was used. Low-density lipoprotein served as a carrier to enhance selective targeting of vascular endothelial cells. Results: Complete choriocapillary occlusion was achieved at a BPD dose of 2 mg/ kg and a radiant exposure as low as 10 J/cm2. When PDT was performed 3 hours after BPD application, damage to the neural retina was minimal. Only inner photoreceptor segments showed mitochondrial swelling probably secondary to choroidal ischemia. Bruch's membrane remained intact. Retinal pigment epithelium was invariably damaged as seen with other photosensitizers. Conclusion: Compared with photocoagulation BPD-PDT allows endothelial-bound intraluminal photothrombosis, sparing important structures such as neural retina and Bruch's membrane. It may thus provide a more selective treatment of juxtafoveal and subfoveal neovascular membranes.",
author = "U. Schmidt-Erfurth and T. Hasan and E. Gragoudas and N. Michaud and Flotte, {Thomas J} and R. Birngruber",
year = "1994",
language = "English (US)",
volume = "101",
pages = "1953--1961",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "12",

}

TY - JOUR

T1 - Vascular targeting in photodynamic occlusion of subretinal vessels

AU - Schmidt-Erfurth, U.

AU - Hasan, T.

AU - Gragoudas, E.

AU - Michaud, N.

AU - Flotte, Thomas J

AU - Birngruber, R.

PY - 1994

Y1 - 1994

N2 - Purpose: To evaluate the potential of photodynamic therapy (PDT) using benzoporphyrin derivative (BPD) for occlusion of subretinal neovascular membranes, the authors studied efficiency and collateral damage of PDT- induced photothrombosis in the rabbit choriocapillary layer. Method: Benzoporphyrin derivative, a new photosensitizer, currently in clinical trials for tumor therapy, was used. Low-density lipoprotein served as a carrier to enhance selective targeting of vascular endothelial cells. Results: Complete choriocapillary occlusion was achieved at a BPD dose of 2 mg/ kg and a radiant exposure as low as 10 J/cm2. When PDT was performed 3 hours after BPD application, damage to the neural retina was minimal. Only inner photoreceptor segments showed mitochondrial swelling probably secondary to choroidal ischemia. Bruch's membrane remained intact. Retinal pigment epithelium was invariably damaged as seen with other photosensitizers. Conclusion: Compared with photocoagulation BPD-PDT allows endothelial-bound intraluminal photothrombosis, sparing important structures such as neural retina and Bruch's membrane. It may thus provide a more selective treatment of juxtafoveal and subfoveal neovascular membranes.

AB - Purpose: To evaluate the potential of photodynamic therapy (PDT) using benzoporphyrin derivative (BPD) for occlusion of subretinal neovascular membranes, the authors studied efficiency and collateral damage of PDT- induced photothrombosis in the rabbit choriocapillary layer. Method: Benzoporphyrin derivative, a new photosensitizer, currently in clinical trials for tumor therapy, was used. Low-density lipoprotein served as a carrier to enhance selective targeting of vascular endothelial cells. Results: Complete choriocapillary occlusion was achieved at a BPD dose of 2 mg/ kg and a radiant exposure as low as 10 J/cm2. When PDT was performed 3 hours after BPD application, damage to the neural retina was minimal. Only inner photoreceptor segments showed mitochondrial swelling probably secondary to choroidal ischemia. Bruch's membrane remained intact. Retinal pigment epithelium was invariably damaged as seen with other photosensitizers. Conclusion: Compared with photocoagulation BPD-PDT allows endothelial-bound intraluminal photothrombosis, sparing important structures such as neural retina and Bruch's membrane. It may thus provide a more selective treatment of juxtafoveal and subfoveal neovascular membranes.

UR - http://www.scopus.com/inward/record.url?scp=0028566497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028566497&partnerID=8YFLogxK

M3 - Article

C2 - 7997334

AN - SCOPUS:0028566497

VL - 101

SP - 1953

EP - 1961

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 12

ER -