TY - JOUR
T1 - Vascular surgery patients
T2 - Perioperative and long-term risk according to the ACC/AHA guidelines, the additive role of post-operative troponin elevation
AU - Bursi, Francesca
AU - Babuin, Luciano
AU - Barbieri, Andrea
AU - Politi, Luigi
AU - Zennaro, Mauro
AU - Grimaldi, Teresa
AU - Rumolo, Antonio
AU - Gargiulo, Mauro
AU - Stella, Andrea
AU - Modena, Maria Grazia
AU - Jaffe, Allan S.
N1 - Funding Information:
The study was supported by a grant from the Ministero dell’ Universita e della Ricerca Scientifica e Tecnologica (MURST). We thank Diane Grill, MS, from Health Science Research Department of Mayo Clinic for the statistical support.
PY - 2005/11
Y1 - 2005/11
N2 - Aims: The objectives of this study are to evaluate the prognostic role of pre-operative stratification in patients undergoing elective major vascular surgery, the timing of adverse outcomes, and the predictive role of troponin (cTn). Methods and results: Consecutive vascular surgery candidates (n = 391) were prospectively stratified and treated according to the ACC/AHA guidelines. The patients were categorized into three groups: (1) with coronary revascularization in the past 5 years, (2) with intermediate clinical risk predictors, and (3) with minor or no clinical risk predictors. cTnI was measured post-operatively. By 18 months, 18.7% of subjects had experienced death or acute myocardial infarction (MI) (by the ACC/ESC criteria). The hazard ratio (HR) was 5.21 (95% CI = 2.60-10.43; P < 0.0001) in group 1 and 2.58 (95% CI = 1.27-4.38; P = 0.004) in group 2 when compared with group 3. Most events occurred within 30 days. Elevations of cTnI were associated with adverse outcomes even after multivariable adjustment at long-term (adjusted overall HR = 4.73, 95% CI = 2.92-7.65; P<0.0001) and at 30 days (adjusted HR = 5.52, 95%CI = 3.23-9.42; P < 0.0001). Conclusion: After pre-operative stratification, patients undergoing elective major vascular surgery remain at high risk of MI and death. Events occur mainly early after surgery. cTnI elevations are frequent and independently associated with increased risk. These findings suggest the need for a major re-evaluation of our approach to these patients.
AB - Aims: The objectives of this study are to evaluate the prognostic role of pre-operative stratification in patients undergoing elective major vascular surgery, the timing of adverse outcomes, and the predictive role of troponin (cTn). Methods and results: Consecutive vascular surgery candidates (n = 391) were prospectively stratified and treated according to the ACC/AHA guidelines. The patients were categorized into three groups: (1) with coronary revascularization in the past 5 years, (2) with intermediate clinical risk predictors, and (3) with minor or no clinical risk predictors. cTnI was measured post-operatively. By 18 months, 18.7% of subjects had experienced death or acute myocardial infarction (MI) (by the ACC/ESC criteria). The hazard ratio (HR) was 5.21 (95% CI = 2.60-10.43; P < 0.0001) in group 1 and 2.58 (95% CI = 1.27-4.38; P = 0.004) in group 2 when compared with group 3. Most events occurred within 30 days. Elevations of cTnI were associated with adverse outcomes even after multivariable adjustment at long-term (adjusted overall HR = 4.73, 95% CI = 2.92-7.65; P<0.0001) and at 30 days (adjusted HR = 5.52, 95%CI = 3.23-9.42; P < 0.0001). Conclusion: After pre-operative stratification, patients undergoing elective major vascular surgery remain at high risk of MI and death. Events occur mainly early after surgery. cTnI elevations are frequent and independently associated with increased risk. These findings suggest the need for a major re-evaluation of our approach to these patients.
KW - Risk stratification
KW - Troponin
KW - Vascular surgery
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U2 - 10.1093/eurheartj/ehi430
DO - 10.1093/eurheartj/ehi430
M3 - Article
C2 - 16055493
AN - SCOPUS:27644483902
SN - 0195-668X
VL - 26
SP - 2448
EP - 2456
JO - European heart journal
JF - European heart journal
IS - 22
ER -