Vascular risk factors and dementia: How to move forward?

Anand Viswanathan, Walter A Rocca, Christophe Tzourio

Research output: Contribution to journalArticle

279 Citations (Scopus)

Abstract

In recent years, accumulating evidence has suggested that vascular risk factors contribute to Alzheimer disease (AD). Vascular dementia had been traditionally considered secondary to stroke and vascular disease. It has been traditionally distinguished from AD, considered to be a purely neurodegenerative form of dementia. However, in light of this more recent literature, it appears that there is a spectrum: ranging from patients with pure vascular dementia to patients with pure AD and including a large majority of patients with contributions from both Alzheimer and vascular pathologies. In this article, we discuss the impact of vascular risk factors on AD and its consequences at the individual level and at the population level by highlighting the concept of attributable risk. We then discuss the key questions and next steps involved in designing a therapeutic trial to control vascular risk factors for the prevention of dementia.

Original languageEnglish (US)
Pages (from-to)368-374
Number of pages7
JournalNeurology
Volume72
Issue number4
DOIs
StatePublished - Jan 27 2009

Fingerprint

Vascular Dementia
Alzheimer Disease
Dementia
Vascular Diseases
Blood Vessels
Stroke
Pathology
vascular factor
Population
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Vascular risk factors and dementia : How to move forward? / Viswanathan, Anand; Rocca, Walter A; Tzourio, Christophe.

In: Neurology, Vol. 72, No. 4, 27.01.2009, p. 368-374.

Research output: Contribution to journalArticle

Viswanathan, Anand ; Rocca, Walter A ; Tzourio, Christophe. / Vascular risk factors and dementia : How to move forward?. In: Neurology. 2009 ; Vol. 72, No. 4. pp. 368-374.
@article{4fce7290b2aa40299ed98347b36ba7f2,
title = "Vascular risk factors and dementia: How to move forward?",
abstract = "In recent years, accumulating evidence has suggested that vascular risk factors contribute to Alzheimer disease (AD). Vascular dementia had been traditionally considered secondary to stroke and vascular disease. It has been traditionally distinguished from AD, considered to be a purely neurodegenerative form of dementia. However, in light of this more recent literature, it appears that there is a spectrum: ranging from patients with pure vascular dementia to patients with pure AD and including a large majority of patients with contributions from both Alzheimer and vascular pathologies. In this article, we discuss the impact of vascular risk factors on AD and its consequences at the individual level and at the population level by highlighting the concept of attributable risk. We then discuss the key questions and next steps involved in designing a therapeutic trial to control vascular risk factors for the prevention of dementia.",
author = "Anand Viswanathan and Rocca, {Walter A} and Christophe Tzourio",
year = "2009",
month = "1",
day = "27",
doi = "10.1212/01.wnl.0000341271.90478.8e",
language = "English (US)",
volume = "72",
pages = "368--374",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Vascular risk factors and dementia

T2 - How to move forward?

AU - Viswanathan, Anand

AU - Rocca, Walter A

AU - Tzourio, Christophe

PY - 2009/1/27

Y1 - 2009/1/27

N2 - In recent years, accumulating evidence has suggested that vascular risk factors contribute to Alzheimer disease (AD). Vascular dementia had been traditionally considered secondary to stroke and vascular disease. It has been traditionally distinguished from AD, considered to be a purely neurodegenerative form of dementia. However, in light of this more recent literature, it appears that there is a spectrum: ranging from patients with pure vascular dementia to patients with pure AD and including a large majority of patients with contributions from both Alzheimer and vascular pathologies. In this article, we discuss the impact of vascular risk factors on AD and its consequences at the individual level and at the population level by highlighting the concept of attributable risk. We then discuss the key questions and next steps involved in designing a therapeutic trial to control vascular risk factors for the prevention of dementia.

AB - In recent years, accumulating evidence has suggested that vascular risk factors contribute to Alzheimer disease (AD). Vascular dementia had been traditionally considered secondary to stroke and vascular disease. It has been traditionally distinguished from AD, considered to be a purely neurodegenerative form of dementia. However, in light of this more recent literature, it appears that there is a spectrum: ranging from patients with pure vascular dementia to patients with pure AD and including a large majority of patients with contributions from both Alzheimer and vascular pathologies. In this article, we discuss the impact of vascular risk factors on AD and its consequences at the individual level and at the population level by highlighting the concept of attributable risk. We then discuss the key questions and next steps involved in designing a therapeutic trial to control vascular risk factors for the prevention of dementia.

UR - http://www.scopus.com/inward/record.url?scp=60549098398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60549098398&partnerID=8YFLogxK

U2 - 10.1212/01.wnl.0000341271.90478.8e

DO - 10.1212/01.wnl.0000341271.90478.8e

M3 - Article

C2 - 19171835

AN - SCOPUS:60549098398

VL - 72

SP - 368

EP - 374

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 4

ER -