TY - JOUR
T1 - Vascular effects of prostacyclin
T2 - Does activation of PPARδ play a role?
AU - Katusic, Zvonimir S.
AU - Santhanam, Anantha V.
AU - He, Tongrong
N1 - Funding Information:
This work was supported by National Institutes of Health grants HL-91867 and HL-111062 to Z.S.K., by American Heart Association Scientist Development Grants 08-35436N to A.S., and 09-DG2190046 to T.H., and by the Mayo Foundation.
PY - 2012/10
Y1 - 2012/10
N2 - Prostacyclin (PGI2) is a potent vasodilator that exerts multiple vasoprotective effects in the cardiovascular system. The effects of PGI 2 are mediated by activation of the cell membrane G-protein-coupled PGI2 receptor (IP receptor). More recently, however, it has been suggested that PGI2 might also serve as an endogenous ligand and activator of nuclear peroxisome proliferator-activated receptorδ (PPARδ). Consistent with this concept, studies designed to define pharmacological properties of stable PGI2 analogs revealed that beneficial effects of these compounds appear to be mediated, in part, by activation of PPARδ. This review discusses emerging evidence regarding the contribution of PPARδ activation to vasoprotective and regenerative functions of PGI2 and stable analogs of PGI2.
AB - Prostacyclin (PGI2) is a potent vasodilator that exerts multiple vasoprotective effects in the cardiovascular system. The effects of PGI 2 are mediated by activation of the cell membrane G-protein-coupled PGI2 receptor (IP receptor). More recently, however, it has been suggested that PGI2 might also serve as an endogenous ligand and activator of nuclear peroxisome proliferator-activated receptorδ (PPARδ). Consistent with this concept, studies designed to define pharmacological properties of stable PGI2 analogs revealed that beneficial effects of these compounds appear to be mediated, in part, by activation of PPARδ. This review discusses emerging evidence regarding the contribution of PPARδ activation to vasoprotective and regenerative functions of PGI2 and stable analogs of PGI2.
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U2 - 10.1016/j.tips.2012.05.005
DO - 10.1016/j.tips.2012.05.005
M3 - Review article
C2 - 22727878
AN - SCOPUS:84866742055
SN - 0165-6147
VL - 33
SP - 559
EP - 564
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 10
ER -