Vascular effects of prostacyclin: Does activation of PPARδ play a role?

Zvonimir S. Katusic, Anantha V. Santhanam, Tongrong He

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Prostacyclin (PGI2) is a potent vasodilator that exerts multiple vasoprotective effects in the cardiovascular system. The effects of PGI 2 are mediated by activation of the cell membrane G-protein-coupled PGI2 receptor (IP receptor). More recently, however, it has been suggested that PGI2 might also serve as an endogenous ligand and activator of nuclear peroxisome proliferator-activated receptorδ (PPARδ). Consistent with this concept, studies designed to define pharmacological properties of stable PGI2 analogs revealed that beneficial effects of these compounds appear to be mediated, in part, by activation of PPARδ. This review discusses emerging evidence regarding the contribution of PPARδ activation to vasoprotective and regenerative functions of PGI2 and stable analogs of PGI2.

Original languageEnglish (US)
Pages (from-to)559-564
Number of pages6
JournalTrends in Pharmacological Sciences
Volume33
Issue number10
DOIs
StatePublished - Oct 1 2012

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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