TY - JOUR
T1 - Vascular cognitive impairment
AU - Graff-Radford, Jonathan
N1 - Funding Information:
Dr. Graff-Radford receives research/grant support from the National Institute on Aging/National Institutes of Health (K76AG057015).
Funding Information:
Research reported in this article was supported by the National Institute on Aging/National Institutes of Health (K76AG057015).
Publisher Copyright:
© Lippincott Williams & Wilkins. © 2019 American Academy of Neurology.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - PURPOSE OF REVIEW This article provides an overview of vascular cognitive impairment; discusses its epidemiology, subtypes, and associations with other neurodegenerative diseases; and reviews the diagnostic evaluation and management of these disorders. RECENT FINDINGS Cerebrovascular disease is a common cause of dementia and frequently coexists with neurodegenerative causes. The heterogeneity of mechanisms leading to vascular cognitive impairment makes developing unifying clinical and research criteria difficult. Recognizing the neuroimaging hallmarks of different forms of vascular cognitive impairment can allow for individualized treatment and management. In individuals with mild vascular cognitive impairment, aerobic exercise appears to be a promising treatment but requires further investigation. SUMMARY Vascular cognitive impairment can be caused by several mechanisms. While treating vascular risk factors is rational to prevent worsening of cognitive impairment, well-designed studies are needed to demonstrate efficacy.
AB - PURPOSE OF REVIEW This article provides an overview of vascular cognitive impairment; discusses its epidemiology, subtypes, and associations with other neurodegenerative diseases; and reviews the diagnostic evaluation and management of these disorders. RECENT FINDINGS Cerebrovascular disease is a common cause of dementia and frequently coexists with neurodegenerative causes. The heterogeneity of mechanisms leading to vascular cognitive impairment makes developing unifying clinical and research criteria difficult. Recognizing the neuroimaging hallmarks of different forms of vascular cognitive impairment can allow for individualized treatment and management. In individuals with mild vascular cognitive impairment, aerobic exercise appears to be a promising treatment but requires further investigation. SUMMARY Vascular cognitive impairment can be caused by several mechanisms. While treating vascular risk factors is rational to prevent worsening of cognitive impairment, well-designed studies are needed to demonstrate efficacy.
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U2 - 10.1212/CON.0000000000000684
DO - 10.1212/CON.0000000000000684
M3 - Review article
C2 - 30707191
AN - SCOPUS:85060954337
SN - 1080-2371
VL - 25
SP - 147
EP - 164
JO - Continuum (Minneapolis, Minn.)
JF - Continuum (Minneapolis, Minn.)
IS - 1
ER -