Vascular anatomic variation in rabbits

Yong Hong Ding, Daying Dai, Kennith F. Layton, Debra A. Lewis, Mark A. Danielson, Ramanathan D Kadirvel, Harry J. Cloft, David F Kallmes

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

PURPOSE: To explore the vascular anatomic variation along the aortic arch in New Zealand White rabbits with the goal of highlighting potential anatomic configurations that might be encountered in the performance of preclinical endovascular research in rabbits. MATERIALS AND METHODS: Digital subtraction angiography images of the brachiocephalic artery (BCA) and aortic arch in New Zealand White rabbits were obtained after creation of elastase-induced aneurysms at the origin of the right common carotid artery (RCCA) in 214 animals. The patterns of origin of the RCCA and left common carotid artery (LCCA), right subclavian artery (RSCA) and left subclavian artery (LSCA), and right vertebral artery (RVA) and left vertebral artery (LVA) were analyzed. RESULTS: Five predominant variations of vessel origin were identified. In 200 of 214 cases (93%), the LCCA originated from the bifurcation of the BCA and aorta. In eight cases (4%), the LCCA directly originated from the aorta. In two cases (1%), the LCCA originated from the BCA. Aberrant RSCA anatomy in which the RSCA originated from the aortic arch instead of the BCA was found in three cases (1.5%). In a single case (0.5%), aberrant RSCA anatomy with the RVA originating from the BCA was encountered. CONCLUSIONS: Anatomic variation of the BCA in New Zealand White rabbits is similar to that seen in humans. Understanding of the normal and variant anatomy of the rabbit will aid investigators who use the rabbit model for endovascular research.

Original languageEnglish (US)
Pages (from-to)1031-1035
Number of pages5
JournalJournal of Vascular and Interventional Radiology
Volume17
Issue number6
DOIs
StatePublished - Jun 2006

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Anatomic Variation
Common Carotid Artery
Blood Vessels
Arteries
Rabbits
Subclavian Artery
Vertebral Artery
Thoracic Aorta
Anatomy
Aorta
Digital Subtraction Angiography
Pancreatic Elastase
Research
Aneurysm
Research Personnel

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Vascular anatomic variation in rabbits. / Ding, Yong Hong; Dai, Daying; Layton, Kennith F.; Lewis, Debra A.; Danielson, Mark A.; Kadirvel, Ramanathan D; Cloft, Harry J.; Kallmes, David F.

In: Journal of Vascular and Interventional Radiology, Vol. 17, No. 6, 06.2006, p. 1031-1035.

Research output: Contribution to journalArticle

Ding, Yong Hong ; Dai, Daying ; Layton, Kennith F. ; Lewis, Debra A. ; Danielson, Mark A. ; Kadirvel, Ramanathan D ; Cloft, Harry J. ; Kallmes, David F. / Vascular anatomic variation in rabbits. In: Journal of Vascular and Interventional Radiology. 2006 ; Vol. 17, No. 6. pp. 1031-1035.
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