Vasa previa: a multicenter retrospective cohort study

Hadi Erfani, Sina Haeri, Scott A. Shainker, Antonio F. Saad, Rodrigo Ruano, Timothy N. Dunn, Atefeh Rezaei, Soroush Aalipour, Ahmed A. Nassr, Amir A. Shamshirsaz, Micah Vaughn, William Lindsley, Melissa H. Spiel, Sherif A. Shazly, Eniola R. Ibirogba, Steven L. Clark, George R. Saade, Michael A. Belfort, Alireza A. Shamshirsaz

Research output: Contribution to journalArticle

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Abstract

Objective: The objective of the study was to describe the characteristics and outcomes of patients with antenatal diagnosis of vasa previa and evaluate the predictive factors of resolution in a contemporary large, multicenter data set. Study Design: This was a retrospective multicenter cohort study of all antenatally diagnosed cases of vasa previa, identified via ultrasound and electronic medical record, between January 2011 and July 2018 in 5 US centers. Records were abstracted to obtain variables at diagnosis, throughout pregnancy, and outcomes, including maternal and neonatal variables. Data were reported as median [range] or n (percentage). Descriptive statistics, receiver-operating characteristics, and logistic regression analysis were used as appropriate. Results: One hundred thirty-six cases of vasa previa were identified in 5 centers during the study period, 19 (14%) of which resolved spontaneously at median estimated gestational age of 27 weeks [19–34]. All subjects with unresolved vasa previa underwent cesarean delivery at a median estimated gestational age of 34 weeks [27–39] with the median estimated blood loss of 800 mL [250–2000]. Rates for vaginal bleeding, preterm labor, premature rupture of membrane, and need for blood product transfusion were not different between the resolved and unresolved group (P = NS). The odds ratio for resolution in those with the estimated gestational age of less than 24 weeks at the time of diagnosis was 7.9 (95% confidence interval, 2.1–29.4) after adjustment for confounding variables. Conclusion: Our data suggest that outcomes in antenatally diagnosed cases of vasa previa are excellent. Furthermore, our data report a higher chance of resolution when the condition is diagnosed before 24 weeks of gestation.

Original languageEnglish (US)
JournalAmerican journal of obstetrics and gynecology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Vasa Previa
Cohort Studies
Retrospective Studies
Gestational Age
Confounding Factors (Epidemiology)
Uterine Hemorrhage
Premature Obstetric Labor
Electronic Health Records
Pregnancy Outcome
Prenatal Diagnosis
ROC Curve
Blood Transfusion
Multicenter Studies
Logistic Models
Odds Ratio
Regression Analysis
Mothers
Confidence Intervals
Pregnancy

Keywords

  • contemporary multicenter study
  • estimated gestational age at diagnosis
  • fetal mortality
  • maternal morbidity
  • resolution
  • vasa previa

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Erfani, H., Haeri, S., Shainker, S. A., Saad, A. F., Ruano, R., Dunn, T. N., ... Shamshirsaz, A. A. (Accepted/In press). Vasa previa: a multicenter retrospective cohort study. American journal of obstetrics and gynecology. https://doi.org/10.1016/j.ajog.2019.06.006

Vasa previa : a multicenter retrospective cohort study. / Erfani, Hadi; Haeri, Sina; Shainker, Scott A.; Saad, Antonio F.; Ruano, Rodrigo; Dunn, Timothy N.; Rezaei, Atefeh; Aalipour, Soroush; Nassr, Ahmed A.; Shamshirsaz, Amir A.; Vaughn, Micah; Lindsley, William; Spiel, Melissa H.; Shazly, Sherif A.; Ibirogba, Eniola R.; Clark, Steven L.; Saade, George R.; Belfort, Michael A.; Shamshirsaz, Alireza A.

In: American journal of obstetrics and gynecology, 01.01.2019.

Research output: Contribution to journalArticle

Erfani, H, Haeri, S, Shainker, SA, Saad, AF, Ruano, R, Dunn, TN, Rezaei, A, Aalipour, S, Nassr, AA, Shamshirsaz, AA, Vaughn, M, Lindsley, W, Spiel, MH, Shazly, SA, Ibirogba, ER, Clark, SL, Saade, GR, Belfort, MA & Shamshirsaz, AA 2019, 'Vasa previa: a multicenter retrospective cohort study', American journal of obstetrics and gynecology. https://doi.org/10.1016/j.ajog.2019.06.006
Erfani, Hadi ; Haeri, Sina ; Shainker, Scott A. ; Saad, Antonio F. ; Ruano, Rodrigo ; Dunn, Timothy N. ; Rezaei, Atefeh ; Aalipour, Soroush ; Nassr, Ahmed A. ; Shamshirsaz, Amir A. ; Vaughn, Micah ; Lindsley, William ; Spiel, Melissa H. ; Shazly, Sherif A. ; Ibirogba, Eniola R. ; Clark, Steven L. ; Saade, George R. ; Belfort, Michael A. ; Shamshirsaz, Alireza A. / Vasa previa : a multicenter retrospective cohort study. In: American journal of obstetrics and gynecology. 2019.
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AU - Ruano, Rodrigo

AU - Dunn, Timothy N.

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