Variation in vaccine response in normal populations

Inna G. Ovsyannikova, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

Genetic polymorphisms of the human leukocyte antigen (HLA) system significantly influence the variation in immune responses to viral vaccines. Considerable data on the genetic determinants of immune responses to the measles vaccine support the importance of HLA genes in determining the variation in vaccine response. HLA class I and class II, TAP, and HLA-DM allele associations with measles-specific antibody levels following measles vaccination have revealed, in part, the immunologic basis for mechanisms of measles immunity variation. Associations between HLA genotype and immune responses have also been reported for other vaccines and infectious diseases, such as hepatitis B and C, human papillomaviruses, and influenza. Vaccine pharmacogenomics may provide important insights for the design and development of new peptide-based vaccines against measles and other pathogens. 2004

Original languageEnglish (US)
Pages (from-to)417-427
Number of pages11
JournalPharmacogenomics
Volume5
Issue number4
DOIs
StatePublished - Jun 1 2004

Keywords

  • Antibody level
  • Antigen processing
  • HLA class I
  • HLA-DM
  • II and III genes
  • Peptides
  • Polymorphisms
  • TAP
  • Vaccine response
  • Variation in immune response

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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    Ovsyannikova, I. G., Jacobson, R. M., & Poland, G. A. (2004). Variation in vaccine response in normal populations. Pharmacogenomics, 5(4), 417-427. https://doi.org/10.1517/14622416.5.4.417