Variation in treatment recommendations of adjuvant radiation therapy for high-risk prostate cancer by physician specialty

Simon P. Kim, Jon C. Tilburt, R. Jeffrey Karnes, Jeanette Y. Ziegenfuss, Leona C. Han, Nilay D. Shah, Igor Frank, Marc C. Smaldone, Cary P. Gross, James B. Yu, Quoc Dien Trinh, Maxine Sun, Rebecca L. O'Malley, Paul L. Nguyen

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Objective To assess the treatment recommendations from a nationally representative sample of radiation oncologists and urologists on adjuvant radiotherapy for patients with pathologically advanced prostate cancer after radical prostatectomy. Methods From a random sample of 1422 physicians (n = 711 radiation oncologists; n = 711 urologists) in the American Medical Association Masterfile, a mail survey queried treatment recommendations for adjuvant radiotherapy that varied by the following pathologic features: extraprostatic extension (pT3a) vs seminal vesicle invasion (pT3b), Gleason 7 vs Gleason 8-10, and margin negative (MN) vs margin positive (MP). Pearson chi-square and multivariable logistic regression were used to test for differences in treatment recommendations by physician specialty. Results Response rates for radiation oncologists and urologists were similar (44% vs 46%; P =.42). Radiation oncologists were more likely to recommend adjuvant radiotherapy than urologists for all the varying pathologic scenarios from pT3a, Gleason 7, and MN (42.5% vs 9.7%; adjusted odds ratio [OR]: 7.82, P <.001) to pT3b, Gleason 8-10, and MP disease (94.5% vs 89.1%, adjusted OR: 2.46, P <.001). Compared with radiation oncologists, urologists were more likely to recommend salvage radiotherapy pT3a, Gleason 7, and MN (90.3% vs 57.7%; adjusted OR: 7.72, P <.001) to pT3b, Gleason 8-10, and MP disease (10.9% vs 5.5%; adjusted OR: 2.22, P <.001). Conclusion In this national survey, radiation oncologists and urologists have markedly different treatment recommendations for adjuvant and salvage radiotherapy. Patients with adverse pathologic features after radical prostatectomy should consult with both a urologist and radiation oncologist to hear a diversity of opinions to make the most informed decision possible.

Original languageEnglish (US)
Pages (from-to)807-813
Number of pages7
JournalUrology
Volume82
Issue number4
DOIs
StatePublished - Oct 2013

ASJC Scopus subject areas

  • Urology

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    Kim, S. P., Tilburt, J. C., Karnes, R. J., Ziegenfuss, J. Y., Han, L. C., Shah, N. D., Frank, I., Smaldone, M. C., Gross, C. P., Yu, J. B., Trinh, Q. D., Sun, M., O'Malley, R. L., & Nguyen, P. L. (2013). Variation in treatment recommendations of adjuvant radiation therapy for high-risk prostate cancer by physician specialty. Urology, 82(4), 807-813. https://doi.org/10.1016/j.urology.2013.04.060