Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD

Amanda J. Myers; Helen Marshall; Peter Holmans; Danielle Compton; Richard J.P. Crook; Adrian P. Mander; Petra Nowotny; Scott Smemo; Melanie Dunstan; Luke Jehu; Jen C. Wang; Marian Hamshere; John C. Morris; Joanne Norton; Sumi Chakraventy; Nigel Tunstall; Simon Lovestone; Ronald Petersen; Michael O'Donovan; Lesley Jones; Julie Williams; Michael J. Owen; John Hardy; Alison Goate

doi:10.1002/ajmg.b.20036

Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD

Amanda J. Myers, Helen Marshall, Peter Holmans, Danielle Compton, Richard J.P. Crook, Adrian P. Mander, Petra Nowotny, Scott Smemo, Melanie Dunstan, Luke Jehu, Jen C. Wang, Marian Hamshere, John C. Morris, Joanne Norton, Sumi Chakraventy, Nigel Tunstall, Simon Lovestone, Ronald Petersen, Michael O'Donovan, Lesley JonesJulie Williams, Michael J. Owen, John Hardy, Alison Goate

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Aβ42 levels suggesting that a single locus may influence risk for AD by elevating plasma Aβ42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.

Original language	English (US)
Pages (from-to)	29-37
Number of pages	9
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	124 B
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.b.20036
State	Published - Jan 1 2004

Keywords

Alzheimer disease
Association study
Candidate gene
PLAU
Urokinase-plasminogen activator

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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Myers, A. J., Marshall, H., Holmans, P., Compton, D., Crook, R. J. P., Mander, A. P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L., Wang, J. C., Hamshere, M., Morris, J. C., Norton, J., Chakraventy, S., Tunstall, N., Lovestone, S., Petersen, R., O'Donovan, M., ... Goate, A. (2004). Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD. American Journal of Medical Genetics - Neuropsychiatric Genetics, 124 B(1), 29-37. https://doi.org/10.1002/ajmg.b.20036

Myers, AJ, Marshall, H, Holmans, P, Compton, D, Crook, RJP, Mander, AP, Nowotny, P, Smemo, S, Dunstan, M, Jehu, L, Wang, JC, Hamshere, M, Morris, JC, Norton, J, Chakraventy, S, Tunstall, N, Lovestone, S, Petersen, R, O'Donovan, M, Jones, L, Williams, J, Owen, MJ, Hardy, J & Goate, A 2004, 'Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 124 B, no. 1, pp. 29-37. https://doi.org/10.1002/ajmg.b.20036

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abstract = "Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Aβ42 levels suggesting that a single locus may influence risk for AD by elevating plasma Aβ42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.",

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AU - Lovestone, Simon

AU - Petersen, Ronald

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Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD

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Keywords

ASJC Scopus subject areas

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