Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry

Emelia J. Benjamin, Kenneth M. Rice, Dan E. Arking, Arne Pfeufer, Charlotte Van Noord, Albert V. Smith, Renate B. Schnabel, Joshua C. Bis, Eric Boerwinkle, Moritz F. Sinner, Abbas Dehghan, Steven A. Lubitz, Ralph B. D'Agostino, Thomas Lumley, Georg B. Ehret, Jan Heeringa, Thor Aspelund, Christopher Newton-Cheh, Martin G. Larson, Kristin D. MarcianteElsayed Z. Soliman, Fernando Rivadeneira, Thomas J. Wang, Gudny Eiríksdottir, Daniel Levy, Bruce M. Psaty, Man Li, Alanna Chamberlain, Albert Hofman, Ramachandran S. Vasan, Tamara B. Harris, Jerome I. Rotter, W. H.Linda Kao, Sunil K. Agarwal, Bruno H.Ch Stricker, Ke Wang, Lenore J. Launer, Nicholas L. Smith, Aravinda Chakravarti, André G. Uitterlinden, Philip A. Wolf, Nona Sotoodehnia, Anna Köttgen, Cornelia M. Van Duijn, Thomas Meitinger, Martina Mueller, Siegfried Perz, Gerhard Steinbeck, H. Erich Wichmann, Kathryn L. Lunetta, Susan R. Heckbert, Vilmundur Gudnason, Alvaro Alonso, Stefan Kääb, Patrick T. Ellinor, Jacqueline C.M. Witteman

Research output: Contribution to journalArticle

264 Citations (Scopus)

Abstract

We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10-7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10 -11; combined RR = 1.25; combined P = 1.8 × 10 -15).

Original languageEnglish (US)
Pages (from-to)879-881
Number of pages3
JournalNature Genetics
Volume41
Issue number8
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

Fingerprint

Atrial Fibrillation
Meta-Analysis
Odds Ratio
Genome-Wide Association Study

ASJC Scopus subject areas

  • Genetics

Cite this

Benjamin, E. J., Rice, K. M., Arking, D. E., Pfeufer, A., Van Noord, C., Smith, A. V., ... Witteman, J. C. M. (2009). Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry. Nature Genetics, 41(8), 879-881. https://doi.org/10.1038/ng.416

Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry. / Benjamin, Emelia J.; Rice, Kenneth M.; Arking, Dan E.; Pfeufer, Arne; Van Noord, Charlotte; Smith, Albert V.; Schnabel, Renate B.; Bis, Joshua C.; Boerwinkle, Eric; Sinner, Moritz F.; Dehghan, Abbas; Lubitz, Steven A.; D'Agostino, Ralph B.; Lumley, Thomas; Ehret, Georg B.; Heeringa, Jan; Aspelund, Thor; Newton-Cheh, Christopher; Larson, Martin G.; Marciante, Kristin D.; Soliman, Elsayed Z.; Rivadeneira, Fernando; Wang, Thomas J.; Eiríksdottir, Gudny; Levy, Daniel; Psaty, Bruce M.; Li, Man; Chamberlain, Alanna; Hofman, Albert; Vasan, Ramachandran S.; Harris, Tamara B.; Rotter, Jerome I.; Kao, W. H.Linda; Agarwal, Sunil K.; Stricker, Bruno H.Ch; Wang, Ke; Launer, Lenore J.; Smith, Nicholas L.; Chakravarti, Aravinda; Uitterlinden, André G.; Wolf, Philip A.; Sotoodehnia, Nona; Köttgen, Anna; Van Duijn, Cornelia M.; Meitinger, Thomas; Mueller, Martina; Perz, Siegfried; Steinbeck, Gerhard; Wichmann, H. Erich; Lunetta, Kathryn L.; Heckbert, Susan R.; Gudnason, Vilmundur; Alonso, Alvaro; Kääb, Stefan; Ellinor, Patrick T.; Witteman, Jacqueline C.M.

In: Nature Genetics, Vol. 41, No. 8, 01.08.2009, p. 879-881.

Research output: Contribution to journalArticle

Benjamin, EJ, Rice, KM, Arking, DE, Pfeufer, A, Van Noord, C, Smith, AV, Schnabel, RB, Bis, JC, Boerwinkle, E, Sinner, MF, Dehghan, A, Lubitz, SA, D'Agostino, RB, Lumley, T, Ehret, GB, Heeringa, J, Aspelund, T, Newton-Cheh, C, Larson, MG, Marciante, KD, Soliman, EZ, Rivadeneira, F, Wang, TJ, Eiríksdottir, G, Levy, D, Psaty, BM, Li, M, Chamberlain, A, Hofman, A, Vasan, RS, Harris, TB, Rotter, JI, Kao, WHL, Agarwal, SK, Stricker, BHC, Wang, K, Launer, LJ, Smith, NL, Chakravarti, A, Uitterlinden, AG, Wolf, PA, Sotoodehnia, N, Köttgen, A, Van Duijn, CM, Meitinger, T, Mueller, M, Perz, S, Steinbeck, G, Wichmann, HE, Lunetta, KL, Heckbert, SR, Gudnason, V, Alonso, A, Kääb, S, Ellinor, PT & Witteman, JCM 2009, 'Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry', Nature Genetics, vol. 41, no. 8, pp. 879-881. https://doi.org/10.1038/ng.416
Benjamin EJ, Rice KM, Arking DE, Pfeufer A, Van Noord C, Smith AV et al. Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry. Nature Genetics. 2009 Aug 1;41(8):879-881. https://doi.org/10.1038/ng.416
Benjamin, Emelia J. ; Rice, Kenneth M. ; Arking, Dan E. ; Pfeufer, Arne ; Van Noord, Charlotte ; Smith, Albert V. ; Schnabel, Renate B. ; Bis, Joshua C. ; Boerwinkle, Eric ; Sinner, Moritz F. ; Dehghan, Abbas ; Lubitz, Steven A. ; D'Agostino, Ralph B. ; Lumley, Thomas ; Ehret, Georg B. ; Heeringa, Jan ; Aspelund, Thor ; Newton-Cheh, Christopher ; Larson, Martin G. ; Marciante, Kristin D. ; Soliman, Elsayed Z. ; Rivadeneira, Fernando ; Wang, Thomas J. ; Eiríksdottir, Gudny ; Levy, Daniel ; Psaty, Bruce M. ; Li, Man ; Chamberlain, Alanna ; Hofman, Albert ; Vasan, Ramachandran S. ; Harris, Tamara B. ; Rotter, Jerome I. ; Kao, W. H.Linda ; Agarwal, Sunil K. ; Stricker, Bruno H.Ch ; Wang, Ke ; Launer, Lenore J. ; Smith, Nicholas L. ; Chakravarti, Aravinda ; Uitterlinden, André G. ; Wolf, Philip A. ; Sotoodehnia, Nona ; Köttgen, Anna ; Van Duijn, Cornelia M. ; Meitinger, Thomas ; Mueller, Martina ; Perz, Siegfried ; Steinbeck, Gerhard ; Wichmann, H. Erich ; Lunetta, Kathryn L. ; Heckbert, Susan R. ; Gudnason, Vilmundur ; Alonso, Alvaro ; Kääb, Stefan ; Ellinor, Patrick T. ; Witteman, Jacqueline C.M. / Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry. In: Nature Genetics. 2009 ; Vol. 41, No. 8. pp. 879-881.
@article{379a4c5ac6324603973d54d29d95fb02,
title = "Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry",
abstract = "We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10-7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10 -11; combined RR = 1.25; combined P = 1.8 × 10 -15).",
author = "Benjamin, {Emelia J.} and Rice, {Kenneth M.} and Arking, {Dan E.} and Arne Pfeufer and {Van Noord}, Charlotte and Smith, {Albert V.} and Schnabel, {Renate B.} and Bis, {Joshua C.} and Eric Boerwinkle and Sinner, {Moritz F.} and Abbas Dehghan and Lubitz, {Steven A.} and D'Agostino, {Ralph B.} and Thomas Lumley and Ehret, {Georg B.} and Jan Heeringa and Thor Aspelund and Christopher Newton-Cheh and Larson, {Martin G.} and Marciante, {Kristin D.} and Soliman, {Elsayed Z.} and Fernando Rivadeneira and Wang, {Thomas J.} and Gudny Eir{\'i}ksdottir and Daniel Levy and Psaty, {Bruce M.} and Man Li and Alanna Chamberlain and Albert Hofman and Vasan, {Ramachandran S.} and Harris, {Tamara B.} and Rotter, {Jerome I.} and Kao, {W. H.Linda} and Agarwal, {Sunil K.} and Stricker, {Bruno H.Ch} and Ke Wang and Launer, {Lenore J.} and Smith, {Nicholas L.} and Aravinda Chakravarti and Uitterlinden, {Andr{\'e} G.} and Wolf, {Philip A.} and Nona Sotoodehnia and Anna K{\"o}ttgen and {Van Duijn}, {Cornelia M.} and Thomas Meitinger and Martina Mueller and Siegfried Perz and Gerhard Steinbeck and Wichmann, {H. Erich} and Lunetta, {Kathryn L.} and Heckbert, {Susan R.} and Vilmundur Gudnason and Alvaro Alonso and Stefan K{\"a}{\"a}b and Ellinor, {Patrick T.} and Witteman, {Jacqueline C.M.}",
year = "2009",
month = "8",
day = "1",
doi = "10.1038/ng.416",
language = "English (US)",
volume = "41",
pages = "879--881",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry

AU - Benjamin, Emelia J.

AU - Rice, Kenneth M.

AU - Arking, Dan E.

AU - Pfeufer, Arne

AU - Van Noord, Charlotte

AU - Smith, Albert V.

AU - Schnabel, Renate B.

AU - Bis, Joshua C.

AU - Boerwinkle, Eric

AU - Sinner, Moritz F.

AU - Dehghan, Abbas

AU - Lubitz, Steven A.

AU - D'Agostino, Ralph B.

AU - Lumley, Thomas

AU - Ehret, Georg B.

AU - Heeringa, Jan

AU - Aspelund, Thor

AU - Newton-Cheh, Christopher

AU - Larson, Martin G.

AU - Marciante, Kristin D.

AU - Soliman, Elsayed Z.

AU - Rivadeneira, Fernando

AU - Wang, Thomas J.

AU - Eiríksdottir, Gudny

AU - Levy, Daniel

AU - Psaty, Bruce M.

AU - Li, Man

AU - Chamberlain, Alanna

AU - Hofman, Albert

AU - Vasan, Ramachandran S.

AU - Harris, Tamara B.

AU - Rotter, Jerome I.

AU - Kao, W. H.Linda

AU - Agarwal, Sunil K.

AU - Stricker, Bruno H.Ch

AU - Wang, Ke

AU - Launer, Lenore J.

AU - Smith, Nicholas L.

AU - Chakravarti, Aravinda

AU - Uitterlinden, André G.

AU - Wolf, Philip A.

AU - Sotoodehnia, Nona

AU - Köttgen, Anna

AU - Van Duijn, Cornelia M.

AU - Meitinger, Thomas

AU - Mueller, Martina

AU - Perz, Siegfried

AU - Steinbeck, Gerhard

AU - Wichmann, H. Erich

AU - Lunetta, Kathryn L.

AU - Heckbert, Susan R.

AU - Gudnason, Vilmundur

AU - Alonso, Alvaro

AU - Kääb, Stefan

AU - Ellinor, Patrick T.

AU - Witteman, Jacqueline C.M.

PY - 2009/8/1

Y1 - 2009/8/1

N2 - We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10-7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10 -11; combined RR = 1.25; combined P = 1.8 × 10 -15).

AB - We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10-7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10 -11; combined RR = 1.25; combined P = 1.8 × 10 -15).

UR - http://www.scopus.com/inward/record.url?scp=68149165772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68149165772&partnerID=8YFLogxK

U2 - 10.1038/ng.416

DO - 10.1038/ng.416

M3 - Article

C2 - 19597492

AN - SCOPUS:68149165772

VL - 41

SP - 879

EP - 881

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 8

ER -