Variants in estrogen-related genes and risk of Parkinson's disease

Sun Ju Chung, Sebastian M. Armasu, Joanna M. Biernacka, Timothy G. Lesnick, David N. Rider, Julie M. Cunningham, Demetrius M. Maraganore

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Incidence rates of Parkinson's disease are higher in men than in women at all ages, and these differences may be a result of the neuroprotective effects of estrogen on the nigrostriatal pathway. We investigated the association of common variants in 4 estrogen-related genes with Parkinson's disease. Tagging single-nucleotide polymorphisms in the CYP19A1, ESR1, ESR2, and PRDM2 genes were selected from the International Haplotype Map and genotyped in 1103 Parkinson's disease cases from the upper Midwest of the United States and in 1103 individually matched controls (654 unaffected siblings, and 449 unrelated controls from the same region). Of 137 informative single-nucleotide polymorphisms, 2 PRDM2 single-nucleotide polymorphisms were significantly associated with an increased risk of Parkinson's disease at the Bonferroni-corrected significance level of 0.0004 (rs2744690: OR, 1.54; SE(logOR), .109; 99.96% CI, 1.05-2.26; uncorrected P = .0001; rs2744687: OR, 1.53; SE(logOR), .113; 99.96% CI, 1.03-2.29, uncorrected P = .0002); the association was significant in the women-only stratum but not in the men-only stratum. An additional 6 single-nucleotide polymorphisms in PRDM2, 2 in ESR1, 1 in ESR2, and 1 in CYP19A1 had significant P values in the overall sample before Bonferroni correction. None of the single-nucleotide polymorphisms were significantly associated with age at onset of Parkinson's disease after Bonferroni correction. Our results confirm the association of PRDM2 variants with Parkinson's disease susceptibility, especially in women.

Original languageEnglish (US)
Pages (from-to)1234-1242
Number of pages9
JournalMovement Disorders
Volume26
Issue number7
DOIs
StatePublished - Jun 1 2011

Keywords

  • Common genetic variation
  • Estrogen
  • Genes
  • PRDM2
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Variants in estrogen-related genes and risk of Parkinson's disease'. Together they form a unique fingerprint.

  • Cite this

    Chung, S. J., Armasu, S. M., Biernacka, J. M., Lesnick, T. G., Rider, D. N., Cunningham, J. M., & Maraganore, D. M. (2011). Variants in estrogen-related genes and risk of Parkinson's disease. Movement Disorders, 26(7), 1234-1242. https://doi.org/10.1002/mds.23604