@article{6add1e553c7442bbaee8e4ce33c10b21,
title = "Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels",
abstract = "Background: CCL16 is a chemokine predominantly expressed in the liver, but is also found in the blood and brain, and is known to play important roles in immune response and angiogenesis. Little is known about the gene's regulation. Methods: Here, we test for potential causal SNPs that affect CCL16 protein levels in both blood plasma and cerebrospinal fluid in a genome-wide association study across two datasets. We then use METAL to performed meta-analyses with a significance threshold of p 5x10-8. We removed SNPs where the direction of the effect was different between the two datasets. Results: We identify 10 SNPs associated with increased CCL16 protein levels in both biological fluids. Conclusions: Our results will help understand CCL16's regulation, allowing researchers to better understand the gene's effects on human health.",
keywords = "Association, Blood, Brain, CCL16, Cerebrospinal fluid, Genetics, Plasma",
author = "{for the Alzheimer's Disease Neuroimaging Initiative} and Ebbert, {Mark T.W.} and Staley, {Lyndsay A.} and Joshua Parker and Sheradyn Parker and Matthew Bailey and Michael Weiner and Paul Aisen and Ronald Petersen and Jack, {Clifford R.} and William Jagust and Trojanowki, {John Q.} and Toga, {Arthur W.} and Laurel Beckett and Green, {Robert C.} and Saykin, {Andrew J.} and John Morris and Ridge, {Perry G.} and Goate, {Alison M.} and Kauwe, {John S.K.}",
note = "Funding Information: Publication for this article was funded by Brigham Young University{\textquoteright}s Department of Biology. This article has been published as part of BMC Genomics Volume 17 Supplement 3, 2016: Selected articles from the 12th Annual Biotechnology and Bioinformatics Symposium: genomics. The full contents of the supplement are available online at https://bmcgenomics.biomedcentral.com/ articles/supplements/volume-17-supplement-3. Publisher Copyright: {\textcopyright} 2016 The Author(s).",
year = "2016",
month = jun,
day = "29",
doi = "10.1186/s12864-016-2788-x",
language = "English (US)",
volume = "17",
journal = "BMC Genomics",
issn = "1471-2164",
publisher = "BioMed Central",
}