Variables in photodynamic therapy for Barrett's esophagus

Linda R. Jones, Norris W. Preyer, Jane Buchanan, Daryl M. Reynolds, Herbert C. Wolfsen, Michael B. Wallace, Kanwar R.S. Gill

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Photodynamic therapy with porfimer sodium (PS) is a treatment option for high grade dysplasia associated with Barrett's esophagus. This study sought to investigate the optical properties of Barrett's dysplasia that may be useful in light dosimetry planning and to determine the effect of PS on tissue absorption and scattering. Fiber optic reflectance spectra were collected before and 48 hours after administration of 2 mg/kg PS. Mucosal biopsies were collected at the same locations. According to Monte Carlo analysis, the fiber optic probe sampled only the mucosal layer. A mathematical fit of the reflectance spectra was performed as a function of blood volume fraction, oxygen saturation and scattering. The average calculated blood volume was 100% higher in Barrett's tissue than normal esophageal tissue. The average scattering slope from 620 to 750 nm was 26% higher for Barrett's dysplasia than normal esophageal tissue, indicating an increase in the size of scattering particles. The difference in the scattering amplitude was not statistically significant, suggesting no significant increase in the number of scattering particles. PS tissue content was determined with extraction methods. Changes in the scattering slope due to PS sensitization were observed; however they were not proportional to the extracted PS concentration.

Original languageEnglish (US)
Title of host publication12th World Congress of the International Photodynamic Association - Photodynamic Therapy
Subtitle of host publicationBack to the Future
DOIs
StatePublished - Dec 1 2009
Event12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future - Seattle, WA, United States
Duration: Jun 11 2009Jun 15 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7380
ISSN (Print)1605-7422

Other

Other12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future
CountryUnited States
CitySeattle, WA
Period6/11/096/15/09

Keywords

  • Barrett's esophagus
  • light dosimetry
  • photodynamic therapy
  • porfimer sodium
  • reflectance spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Variables in photodynamic therapy for Barrett's esophagus'. Together they form a unique fingerprint.

  • Cite this

    Jones, L. R., Preyer, N. W., Buchanan, J., Reynolds, D. M., Wolfsen, H. C., Wallace, M. B., & Gill, K. R. S. (2009). Variables in photodynamic therapy for Barrett's esophagus. In 12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future [73800N] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7380). https://doi.org/10.1117/12.822934