Abstract
The goal of this study was to identify factors contributing to hippocampal atrophy rate (HAR) in clinically normal older adults (NC) and participants with mild cognitive impairment (MCI). Longitudinal HAR was measured on T1-weighted magnetic resonance imaging, and the contribution of age, gender, apolipoprotein E (ApoE) ε4 status, intracranial volume, white matter lesions, and β-amyloid (Aβ) levels to HAR was determined using linear regression. Age-related effects of HAR were compared in Aβ positive (Aβ+) and Aβ negative (Aβ-) participants. Age and Aβ levels had independent effects on HAR in NC, whereas gender, ApoE ε4 status, and Aβ levels were associated with HAR in MCI. In multivariable models, Aβ levels were associated with HAR in NC; ApoE ε4 and Aβ levels were associated with HAR in MCI. In MCI, age was a stronger predictor of HAR in Aβ- versus Aβ+ participants. HAR was higher in Aβ+ participants, but most of the HAR was because of factors other than Aβ status. Age-related effects on HAR did not differ between NC versus MCI participants with the same Aβ status. Therefore, we conclude that even when accounting for other covariates, Aβ status, and not age, is a significant predictor of HAR; and that most of the HAR is not accounted for by Aβ status in either NC or MCI.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 273-282 |
| Number of pages | 10 |
| Journal | Neurobiology of Aging |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2015 |
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Keywords
- Alzheimer's disease
- Hippocampal atrophy rate
- Longitudinal study
- Normal aging
- β-amyloid
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
- Aging
- Developmental Biology
- Geriatrics and Gerontology
Cite this
Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment. / Alzheimer's Disease Neuroimaging Initiative.
In: Neurobiology of Aging, Vol. 36, No. 1, 01.01.2015, p. 273-282.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment
AU - Alzheimer's Disease Neuroimaging Initiative
AU - Nosheny, Rachel L.
AU - Insel, Philip S.
AU - Truran, Diana
AU - Schuff, Norbert
AU - Jack, Clifford R Jr.
AU - Aisen, Paul S.
AU - Shaw, Leslie M.
AU - Trojanowski, John Q.
AU - Weiner, Michael W.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - The goal of this study was to identify factors contributing to hippocampal atrophy rate (HAR) in clinically normal older adults (NC) and participants with mild cognitive impairment (MCI). Longitudinal HAR was measured on T1-weighted magnetic resonance imaging, and the contribution of age, gender, apolipoprotein E (ApoE) ε4 status, intracranial volume, white matter lesions, and β-amyloid (Aβ) levels to HAR was determined using linear regression. Age-related effects of HAR were compared in Aβ positive (Aβ+) and Aβ negative (Aβ-) participants. Age and Aβ levels had independent effects on HAR in NC, whereas gender, ApoE ε4 status, and Aβ levels were associated with HAR in MCI. In multivariable models, Aβ levels were associated with HAR in NC; ApoE ε4 and Aβ levels were associated with HAR in MCI. In MCI, age was a stronger predictor of HAR in Aβ- versus Aβ+ participants. HAR was higher in Aβ+ participants, but most of the HAR was because of factors other than Aβ status. Age-related effects on HAR did not differ between NC versus MCI participants with the same Aβ status. Therefore, we conclude that even when accounting for other covariates, Aβ status, and not age, is a significant predictor of HAR; and that most of the HAR is not accounted for by Aβ status in either NC or MCI.
AB - The goal of this study was to identify factors contributing to hippocampal atrophy rate (HAR) in clinically normal older adults (NC) and participants with mild cognitive impairment (MCI). Longitudinal HAR was measured on T1-weighted magnetic resonance imaging, and the contribution of age, gender, apolipoprotein E (ApoE) ε4 status, intracranial volume, white matter lesions, and β-amyloid (Aβ) levels to HAR was determined using linear regression. Age-related effects of HAR were compared in Aβ positive (Aβ+) and Aβ negative (Aβ-) participants. Age and Aβ levels had independent effects on HAR in NC, whereas gender, ApoE ε4 status, and Aβ levels were associated with HAR in MCI. In multivariable models, Aβ levels were associated with HAR in NC; ApoE ε4 and Aβ levels were associated with HAR in MCI. In MCI, age was a stronger predictor of HAR in Aβ- versus Aβ+ participants. HAR was higher in Aβ+ participants, but most of the HAR was because of factors other than Aβ status. Age-related effects on HAR did not differ between NC versus MCI participants with the same Aβ status. Therefore, we conclude that even when accounting for other covariates, Aβ status, and not age, is a significant predictor of HAR; and that most of the HAR is not accounted for by Aβ status in either NC or MCI.
KW - Alzheimer's disease
KW - Hippocampal atrophy rate
KW - Longitudinal study
KW - Normal aging
KW - β-amyloid
UR - http://www.scopus.com/inward/record.url?scp=84920495244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920495244&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2014.07.036
DO - 10.1016/j.neurobiolaging.2014.07.036
M3 - Article
C2 - 25175807
AN - SCOPUS:84920495244
VL - 36
SP - 273
EP - 282
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 1
ER -