Variability of phase shift between blood pressure and heart rate fluctuations: A marker of short-term circulation control

Josef Halámek, Tomáš Kára, Pavel Jurák, Miroslav Souček, Darrel P. Francis, L. Ceri Davies, Win K. Shen, Andrew J S Coats, Miroslav Novák, Zuzana Nováková, Roman Panovský, Jiří Toman, Josef Šumbera, Virend Somers

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background - We postulated that the variability of the phase shift between blood pressure and heart rate fluctuation near the frequency of 0.10 Hz might be useful in assessing autonomic circulatory control. Methods and Results - We tested this hypothesis in 4 groups of subjects: 28 young, healthy individuals; 13 elderly healthy individuals; 25 patients with coronary heart disease; and 19 patients with a planned or implanted cardioverterdefibrillator (ICD recipients). Data from 5 minutes of free breathing and at 2 different, controlled breathing frequencies (0.10 and 0.33 Hz) were used. Clear differences (P<0.001) in variability of phase were evident between the ICD recipients and all other groups. Furthermore, at a breathing frequency of 0.10 Hz, differences in baroreflex sensitivity (P<0.01) also became evident, even though these differences were not apparent at the 0.33-Hz breathing frequency. Conclusions - The frequency of 0.10 Hz represents a useful and potentially important one for controlled breathing, at which differences in blood pressure-RR interactions become evident. These interactions, whether computed as a variability of phase to define stability of the blood pressure-heart rate interaction or defined as the baroreflex sensitivity to define the gain in heart rate response to blood pressure changes, are significantly different in patients at risk for sudden arrhythmic death. In young versus older healthy individuals, only baroreflex gain is different, with the variability of phase being similar in both groups. These measurements of short-term circulatory control might help in risk stratification for sudden cardiac death.

Original languageEnglish (US)
Pages (from-to)292-297
Number of pages6
JournalCirculation
Volume108
Issue number3
DOIs
StatePublished - Jul 22 2003

Fingerprint

Respiration
Heart Rate
Baroreflex
Blood Pressure
Sudden Cardiac Death
Sudden Death
Coronary Disease

Keywords

  • Baroreceptors
  • Death, sudden
  • Respiration

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Variability of phase shift between blood pressure and heart rate fluctuations : A marker of short-term circulation control. / Halámek, Josef; Kára, Tomáš; Jurák, Pavel; Souček, Miroslav; Francis, Darrel P.; Davies, L. Ceri; Shen, Win K.; Coats, Andrew J S; Novák, Miroslav; Nováková, Zuzana; Panovský, Roman; Toman, Jiří; Šumbera, Josef; Somers, Virend.

In: Circulation, Vol. 108, No. 3, 22.07.2003, p. 292-297.

Research output: Contribution to journalArticle

Halámek, J, Kára, T, Jurák, P, Souček, M, Francis, DP, Davies, LC, Shen, WK, Coats, AJS, Novák, M, Nováková, Z, Panovský, R, Toman, J, Šumbera, J & Somers, V 2003, 'Variability of phase shift between blood pressure and heart rate fluctuations: A marker of short-term circulation control', Circulation, vol. 108, no. 3, pp. 292-297. https://doi.org/10.1161/01.CIR.0000079222.91910.EE
Halámek, Josef ; Kára, Tomáš ; Jurák, Pavel ; Souček, Miroslav ; Francis, Darrel P. ; Davies, L. Ceri ; Shen, Win K. ; Coats, Andrew J S ; Novák, Miroslav ; Nováková, Zuzana ; Panovský, Roman ; Toman, Jiří ; Šumbera, Josef ; Somers, Virend. / Variability of phase shift between blood pressure and heart rate fluctuations : A marker of short-term circulation control. In: Circulation. 2003 ; Vol. 108, No. 3. pp. 292-297.
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AU - Halámek, Josef

AU - Kára, Tomáš

AU - Jurák, Pavel

AU - Souček, Miroslav

AU - Francis, Darrel P.

AU - Davies, L. Ceri

AU - Shen, Win K.

AU - Coats, Andrew J S

AU - Novák, Miroslav

AU - Nováková, Zuzana

AU - Panovský, Roman

AU - Toman, Jiří

AU - Šumbera, Josef

AU - Somers, Virend

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N2 - Background - We postulated that the variability of the phase shift between blood pressure and heart rate fluctuation near the frequency of 0.10 Hz might be useful in assessing autonomic circulatory control. Methods and Results - We tested this hypothesis in 4 groups of subjects: 28 young, healthy individuals; 13 elderly healthy individuals; 25 patients with coronary heart disease; and 19 patients with a planned or implanted cardioverterdefibrillator (ICD recipients). Data from 5 minutes of free breathing and at 2 different, controlled breathing frequencies (0.10 and 0.33 Hz) were used. Clear differences (P<0.001) in variability of phase were evident between the ICD recipients and all other groups. Furthermore, at a breathing frequency of 0.10 Hz, differences in baroreflex sensitivity (P<0.01) also became evident, even though these differences were not apparent at the 0.33-Hz breathing frequency. Conclusions - The frequency of 0.10 Hz represents a useful and potentially important one for controlled breathing, at which differences in blood pressure-RR interactions become evident. These interactions, whether computed as a variability of phase to define stability of the blood pressure-heart rate interaction or defined as the baroreflex sensitivity to define the gain in heart rate response to blood pressure changes, are significantly different in patients at risk for sudden arrhythmic death. In young versus older healthy individuals, only baroreflex gain is different, with the variability of phase being similar in both groups. These measurements of short-term circulatory control might help in risk stratification for sudden cardiac death.

AB - Background - We postulated that the variability of the phase shift between blood pressure and heart rate fluctuation near the frequency of 0.10 Hz might be useful in assessing autonomic circulatory control. Methods and Results - We tested this hypothesis in 4 groups of subjects: 28 young, healthy individuals; 13 elderly healthy individuals; 25 patients with coronary heart disease; and 19 patients with a planned or implanted cardioverterdefibrillator (ICD recipients). Data from 5 minutes of free breathing and at 2 different, controlled breathing frequencies (0.10 and 0.33 Hz) were used. Clear differences (P<0.001) in variability of phase were evident between the ICD recipients and all other groups. Furthermore, at a breathing frequency of 0.10 Hz, differences in baroreflex sensitivity (P<0.01) also became evident, even though these differences were not apparent at the 0.33-Hz breathing frequency. Conclusions - The frequency of 0.10 Hz represents a useful and potentially important one for controlled breathing, at which differences in blood pressure-RR interactions become evident. These interactions, whether computed as a variability of phase to define stability of the blood pressure-heart rate interaction or defined as the baroreflex sensitivity to define the gain in heart rate response to blood pressure changes, are significantly different in patients at risk for sudden arrhythmic death. In young versus older healthy individuals, only baroreflex gain is different, with the variability of phase being similar in both groups. These measurements of short-term circulatory control might help in risk stratification for sudden cardiac death.

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KW - Death, sudden

KW - Respiration

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