Variability of performance status assessment between patients with hematologic malignancies and their physicians

Alexis D. Leal, Cristine Allmer, Matthew J. Maurer, Tait D. Shanafelt, James R Cerhan, Brian K. Link, Carrie A Thompson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study was conducted to determine the incidence of inter-observer variability in Eastern Cooperative Oncology Group (ECOG) performance status (PS) rating between patients with leukemia and lymphoma and their physicians. ECOG PS was assessed at diagnosis by patients and their physicians and stratified by disease subtype, gender, age, disease stage and education. Association between patient- and physician-rated PS and overall survival (OS) was stratified by subtype and prognostic risk score. Overall, 65% of patients and physicians rated PS the same. Age, disease stage and disease subtype were significant predictors of PS disagreement. PS was a significant predictor of OS irrespective of assessment by patients or physicians across all subtypes except those with Hodgkin lymphoma. These findings suggest the need for physicians to better communicate with patients when determining PS, as PS is a strong predictor of survival and is critical in treatment decisions, including determining fitness for cancer treatment.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalLeukemia and Lymphoma
DOIs
StateAccepted/In press - Jul 17 2017

Fingerprint

Hematologic Neoplasms
Physicians
Survival
Observer Variation
Hodgkin Disease
Lymphoma
Leukemia
Education
Incidence
Therapeutics
Neoplasms

Keywords

  • cancer
  • inter-observer agreement
  • leukemia
  • lymphoma
  • overall survival
  • Performance status

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Variability of performance status assessment between patients with hematologic malignancies and their physicians. / Leal, Alexis D.; Allmer, Cristine; Maurer, Matthew J.; Shanafelt, Tait D.; Cerhan, James R; Link, Brian K.; Thompson, Carrie A.

In: Leukemia and Lymphoma, 17.07.2017, p. 1-7.

Research output: Contribution to journalArticle

Leal, Alexis D. ; Allmer, Cristine ; Maurer, Matthew J. ; Shanafelt, Tait D. ; Cerhan, James R ; Link, Brian K. ; Thompson, Carrie A. / Variability of performance status assessment between patients with hematologic malignancies and their physicians. In: Leukemia and Lymphoma. 2017 ; pp. 1-7.
@article{808a0a741f1545a09fef82e065132b5a,
title = "Variability of performance status assessment between patients with hematologic malignancies and their physicians",
abstract = "This study was conducted to determine the incidence of inter-observer variability in Eastern Cooperative Oncology Group (ECOG) performance status (PS) rating between patients with leukemia and lymphoma and their physicians. ECOG PS was assessed at diagnosis by patients and their physicians and stratified by disease subtype, gender, age, disease stage and education. Association between patient- and physician-rated PS and overall survival (OS) was stratified by subtype and prognostic risk score. Overall, 65{\%} of patients and physicians rated PS the same. Age, disease stage and disease subtype were significant predictors of PS disagreement. PS was a significant predictor of OS irrespective of assessment by patients or physicians across all subtypes except those with Hodgkin lymphoma. These findings suggest the need for physicians to better communicate with patients when determining PS, as PS is a strong predictor of survival and is critical in treatment decisions, including determining fitness for cancer treatment.",
keywords = "cancer, inter-observer agreement, leukemia, lymphoma, overall survival, Performance status",
author = "Leal, {Alexis D.} and Cristine Allmer and Maurer, {Matthew J.} and Shanafelt, {Tait D.} and Cerhan, {James R} and Link, {Brian K.} and Thompson, {Carrie A}",
year = "2017",
month = "7",
day = "17",
doi = "10.1080/10428194.2017.1347930",
language = "English (US)",
pages = "1--7",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",

}

TY - JOUR

T1 - Variability of performance status assessment between patients with hematologic malignancies and their physicians

AU - Leal, Alexis D.

AU - Allmer, Cristine

AU - Maurer, Matthew J.

AU - Shanafelt, Tait D.

AU - Cerhan, James R

AU - Link, Brian K.

AU - Thompson, Carrie A

PY - 2017/7/17

Y1 - 2017/7/17

N2 - This study was conducted to determine the incidence of inter-observer variability in Eastern Cooperative Oncology Group (ECOG) performance status (PS) rating between patients with leukemia and lymphoma and their physicians. ECOG PS was assessed at diagnosis by patients and their physicians and stratified by disease subtype, gender, age, disease stage and education. Association between patient- and physician-rated PS and overall survival (OS) was stratified by subtype and prognostic risk score. Overall, 65% of patients and physicians rated PS the same. Age, disease stage and disease subtype were significant predictors of PS disagreement. PS was a significant predictor of OS irrespective of assessment by patients or physicians across all subtypes except those with Hodgkin lymphoma. These findings suggest the need for physicians to better communicate with patients when determining PS, as PS is a strong predictor of survival and is critical in treatment decisions, including determining fitness for cancer treatment.

AB - This study was conducted to determine the incidence of inter-observer variability in Eastern Cooperative Oncology Group (ECOG) performance status (PS) rating between patients with leukemia and lymphoma and their physicians. ECOG PS was assessed at diagnosis by patients and their physicians and stratified by disease subtype, gender, age, disease stage and education. Association between patient- and physician-rated PS and overall survival (OS) was stratified by subtype and prognostic risk score. Overall, 65% of patients and physicians rated PS the same. Age, disease stage and disease subtype were significant predictors of PS disagreement. PS was a significant predictor of OS irrespective of assessment by patients or physicians across all subtypes except those with Hodgkin lymphoma. These findings suggest the need for physicians to better communicate with patients when determining PS, as PS is a strong predictor of survival and is critical in treatment decisions, including determining fitness for cancer treatment.

KW - cancer

KW - inter-observer agreement

KW - leukemia

KW - lymphoma

KW - overall survival

KW - Performance status

UR - http://www.scopus.com/inward/record.url?scp=85024500832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85024500832&partnerID=8YFLogxK

U2 - 10.1080/10428194.2017.1347930

DO - 10.1080/10428194.2017.1347930

M3 - Article

SP - 1

EP - 7

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

ER -