Variability of consecutive in vivo MR flow measurements in the main portal vein

Amy K. Hara, David J. Burkart, C. Daniel Johnson, Joel P. Felmlee, Richard Lorne Ehman, Duane M. Ilstrup, W. Scott Harmsen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

OBJECTIVE. The variability of consecutive cine phase-contrast MR flow measurements could significantly affect their use for clinical decisions, especially during provocative testing. The purposes of this study were to determine the normal variability of flow and consecutive flow measurements in the main portal vein on MR images and to determine how intraobserver variability, interobserver variability, and MR imager variability affect these measurements. SUBJECTS AND METHODS. MR flow measurements were acquired four consecutive times at the same location in the main portal vein of 12 subjects and three consecutive times at the same location in a nonpulsatile vessel model. All acquisitions were completed within 10 min. All main portal vein MR data sets were evaluated manually in a blinded review by two independent observers during three separate sessions spaced a mean of 4.5 weeks apart. Flow model data sets were evaluated during a single session by one observer. Variabilities were subsequently calculated by a components-of- variance analysis and by the coefficient of variation (SD/mean x 100). RESULTS. Of the total variance, 90% was due to flow variability among subjects (intersubject), 6% to flow variability within one subject (intrasubject), 2% to intraobserver variability, and 2% to interobserver variability. The coefficient of variation of consecutive MR portal vein flow measurements within a single subject was 11% ± 5% (range, 3-23%). Intra- and interobserver variabilities were 5% ± 2% (range, 1-11%) and 4% ± 4% (range, 017%), respectively. MR imager variability was 1% ± 1% (range, 0-2%). CONCLUSION. The mean variability of consecutive cine phase-contrast MR flow measurements in the main portal vein is 11% ± 5% and could affect research and clinical protocols that employ this technique.

Original languageEnglish (US)
Pages (from-to)1311-1315
Number of pages5
JournalAmerican Journal of Roentgenology
Volume166
Issue number6
StatePublished - Jun 1996

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Observer Variation
Portal Vein
Clinical Protocols
Analysis of Variance

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Hara, A. K., Burkart, D. J., Johnson, C. D., Felmlee, J. P., Ehman, R. L., Ilstrup, D. M., & Harmsen, W. S. (1996). Variability of consecutive in vivo MR flow measurements in the main portal vein. American Journal of Roentgenology, 166(6), 1311-1315.

Variability of consecutive in vivo MR flow measurements in the main portal vein. / Hara, Amy K.; Burkart, David J.; Johnson, C. Daniel; Felmlee, Joel P.; Ehman, Richard Lorne; Ilstrup, Duane M.; Harmsen, W. Scott.

In: American Journal of Roentgenology, Vol. 166, No. 6, 06.1996, p. 1311-1315.

Research output: Contribution to journalArticle

Hara, AK, Burkart, DJ, Johnson, CD, Felmlee, JP, Ehman, RL, Ilstrup, DM & Harmsen, WS 1996, 'Variability of consecutive in vivo MR flow measurements in the main portal vein', American Journal of Roentgenology, vol. 166, no. 6, pp. 1311-1315.
Hara, Amy K. ; Burkart, David J. ; Johnson, C. Daniel ; Felmlee, Joel P. ; Ehman, Richard Lorne ; Ilstrup, Duane M. ; Harmsen, W. Scott. / Variability of consecutive in vivo MR flow measurements in the main portal vein. In: American Journal of Roentgenology. 1996 ; Vol. 166, No. 6. pp. 1311-1315.
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abstract = "OBJECTIVE. The variability of consecutive cine phase-contrast MR flow measurements could significantly affect their use for clinical decisions, especially during provocative testing. The purposes of this study were to determine the normal variability of flow and consecutive flow measurements in the main portal vein on MR images and to determine how intraobserver variability, interobserver variability, and MR imager variability affect these measurements. SUBJECTS AND METHODS. MR flow measurements were acquired four consecutive times at the same location in the main portal vein of 12 subjects and three consecutive times at the same location in a nonpulsatile vessel model. All acquisitions were completed within 10 min. All main portal vein MR data sets were evaluated manually in a blinded review by two independent observers during three separate sessions spaced a mean of 4.5 weeks apart. Flow model data sets were evaluated during a single session by one observer. Variabilities were subsequently calculated by a components-of- variance analysis and by the coefficient of variation (SD/mean x 100). RESULTS. Of the total variance, 90{\%} was due to flow variability among subjects (intersubject), 6{\%} to flow variability within one subject (intrasubject), 2{\%} to intraobserver variability, and 2{\%} to interobserver variability. The coefficient of variation of consecutive MR portal vein flow measurements within a single subject was 11{\%} ± 5{\%} (range, 3-23{\%}). Intra- and interobserver variabilities were 5{\%} ± 2{\%} (range, 1-11{\%}) and 4{\%} ± 4{\%} (range, 017{\%}), respectively. MR imager variability was 1{\%} ± 1{\%} (range, 0-2{\%}). CONCLUSION. The mean variability of consecutive cine phase-contrast MR flow measurements in the main portal vein is 11{\%} ± 5{\%} and could affect research and clinical protocols that employ this technique.",
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T1 - Variability of consecutive in vivo MR flow measurements in the main portal vein

AU - Hara, Amy K.

AU - Burkart, David J.

AU - Johnson, C. Daniel

AU - Felmlee, Joel P.

AU - Ehman, Richard Lorne

AU - Ilstrup, Duane M.

AU - Harmsen, W. Scott

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N2 - OBJECTIVE. The variability of consecutive cine phase-contrast MR flow measurements could significantly affect their use for clinical decisions, especially during provocative testing. The purposes of this study were to determine the normal variability of flow and consecutive flow measurements in the main portal vein on MR images and to determine how intraobserver variability, interobserver variability, and MR imager variability affect these measurements. SUBJECTS AND METHODS. MR flow measurements were acquired four consecutive times at the same location in the main portal vein of 12 subjects and three consecutive times at the same location in a nonpulsatile vessel model. All acquisitions were completed within 10 min. All main portal vein MR data sets were evaluated manually in a blinded review by two independent observers during three separate sessions spaced a mean of 4.5 weeks apart. Flow model data sets were evaluated during a single session by one observer. Variabilities were subsequently calculated by a components-of- variance analysis and by the coefficient of variation (SD/mean x 100). RESULTS. Of the total variance, 90% was due to flow variability among subjects (intersubject), 6% to flow variability within one subject (intrasubject), 2% to intraobserver variability, and 2% to interobserver variability. The coefficient of variation of consecutive MR portal vein flow measurements within a single subject was 11% ± 5% (range, 3-23%). Intra- and interobserver variabilities were 5% ± 2% (range, 1-11%) and 4% ± 4% (range, 017%), respectively. MR imager variability was 1% ± 1% (range, 0-2%). CONCLUSION. The mean variability of consecutive cine phase-contrast MR flow measurements in the main portal vein is 11% ± 5% and could affect research and clinical protocols that employ this technique.

AB - OBJECTIVE. The variability of consecutive cine phase-contrast MR flow measurements could significantly affect their use for clinical decisions, especially during provocative testing. The purposes of this study were to determine the normal variability of flow and consecutive flow measurements in the main portal vein on MR images and to determine how intraobserver variability, interobserver variability, and MR imager variability affect these measurements. SUBJECTS AND METHODS. MR flow measurements were acquired four consecutive times at the same location in the main portal vein of 12 subjects and three consecutive times at the same location in a nonpulsatile vessel model. All acquisitions were completed within 10 min. All main portal vein MR data sets were evaluated manually in a blinded review by two independent observers during three separate sessions spaced a mean of 4.5 weeks apart. Flow model data sets were evaluated during a single session by one observer. Variabilities were subsequently calculated by a components-of- variance analysis and by the coefficient of variation (SD/mean x 100). RESULTS. Of the total variance, 90% was due to flow variability among subjects (intersubject), 6% to flow variability within one subject (intrasubject), 2% to intraobserver variability, and 2% to interobserver variability. The coefficient of variation of consecutive MR portal vein flow measurements within a single subject was 11% ± 5% (range, 3-23%). Intra- and interobserver variabilities were 5% ± 2% (range, 1-11%) and 4% ± 4% (range, 017%), respectively. MR imager variability was 1% ± 1% (range, 0-2%). CONCLUSION. The mean variability of consecutive cine phase-contrast MR flow measurements in the main portal vein is 11% ± 5% and could affect research and clinical protocols that employ this technique.

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