Variability of cerebrospinal fluid findings by attack phenotype in myelin oligodendrocyte glycoprotein-IgG-associated disorder

Elia Sechi; Marina Buciuc; Eoin P. Flanagan; Sean J. Pittock; Samantha A. Banks; A. Sebastian Lopez-Chiriboga; M. Tariq Bhatti; John J. Chen

doi:10.1016/j.msard.2020.102638

Variability of cerebrospinal fluid findings by attack phenotype in myelin oligodendrocyte glycoprotein-IgG-associated disorder

Elia Sechi, Marina Buciuc, Eoin P. Flanagan, Sean J. Pittock, Samantha A. Banks, A. Sebastian Lopez-Chiriboga, M. Tariq Bhatti, John J. Chen

Research output: Contribution to journal › Letter › peer-review

Abstract

Background: The variability in cerebrospinal fluid (CSF) findings of myelin oligodendrocyte glycoprotein-IgG-associated disorder (MOGAD) is not fully elucidated. Objective and Methods: We retrospectively analyzed 203 attack-associated CSFs from Mayo Clinic patients (2000-2019) with MOGAD. Results: White-blood-cell (>5/mm³) elevation was less with clinically isolated optic neuritis (23%), compared to myelitis, brain/brainstem attacks, or combinations thereof (>70%), p<0.0001. CSF pleocytosis in optic neuritis was more common in patients with coexisting asymptomatic brain and/or spine MRI T2-lesions (53%) than in those without (16%), p=0.005. Abnormal CSF oligoclonal bands ranged from 1% (optic neuritis) to 18% (brain/brainstem attacks). CSF pleocytosis was less common after immunotherapy. Conclusions: CSF findings in MOGAD vary by attack phenotype and preceding treatment.

Original language	English (US)
Article number	102638
Journal	Multiple Sclerosis and Related Disorders
Volume	47
DOIs	https://doi.org/10.1016/j.msard.2020.102638
State	Published - Jan 2021

Keywords

(1) MOG
(2) CSF (3) neuromyelitis optica spectrum disorder
(4) NMOSD
(5) oligoclonal bands
(6) optic neuritis

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Variability of cerebrospinal fluid findings by attack phenotype in myelin oligodendrocyte glycoprotein-IgG-associated disorder. / Sechi, Elia; Buciuc, Marina; Flanagan, Eoin P.; Pittock, Sean J.; Banks, Samantha A.; Lopez-Chiriboga, A. Sebastian; Bhatti, M. Tariq; Chen, John J.

In: Multiple Sclerosis and Related Disorders, Vol. 47, 102638, 01.2021.

Research output: Contribution to journal › Letter › peer-review

@article{2dd3d6cf83d84d9d97408808c86a4775,

title = "Variability of cerebrospinal fluid findings by attack phenotype in myelin oligodendrocyte glycoprotein-IgG-associated disorder",

abstract = "Background: The variability in cerebrospinal fluid (CSF) findings of myelin oligodendrocyte glycoprotein-IgG-associated disorder (MOGAD) is not fully elucidated. Objective and Methods: We retrospectively analyzed 203 attack-associated CSFs from Mayo Clinic patients (2000-2019) with MOGAD. Results: White-blood-cell (>5/mm3) elevation was less with clinically isolated optic neuritis (23%), compared to myelitis, brain/brainstem attacks, or combinations thereof (>70%), p<0.0001. CSF pleocytosis in optic neuritis was more common in patients with coexisting asymptomatic brain and/or spine MRI T2-lesions (53%) than in those without (16%), p=0.005. Abnormal CSF oligoclonal bands ranged from 1% (optic neuritis) to 18% (brain/brainstem attacks). CSF pleocytosis was less common after immunotherapy. Conclusions: CSF findings in MOGAD vary by attack phenotype and preceding treatment.",

keywords = "(1) MOG, (2) CSF (3) neuromyelitis optica spectrum disorder, (4) NMOSD, (5) oligoclonal bands, (6) optic neuritis",

author = "Elia Sechi and Marina Buciuc and Flanagan, {Eoin P.} and Pittock, {Sean J.} and Banks, {Samantha A.} and Lopez-Chiriboga, {A. Sebastian} and Bhatti, {M. Tariq} and Chen, {John J.}",

note = "Funding Information: This study was supported by an NIH grant (R01NS113828) and the Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology. ",

year = "2021",

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doi = "10.1016/j.msard.2020.102638",

language = "English (US)",

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journal = "Multiple Sclerosis and Related Disorders",

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T1 - Variability of cerebrospinal fluid findings by attack phenotype in myelin oligodendrocyte glycoprotein-IgG-associated disorder

AU - Sechi, Elia

AU - Buciuc, Marina

AU - Flanagan, Eoin P.

AU - Pittock, Sean J.

AU - Banks, Samantha A.

AU - Lopez-Chiriboga, A. Sebastian

AU - Bhatti, M. Tariq

AU - Chen, John J.

N1 - Funding Information: This study was supported by an NIH grant (R01NS113828) and the Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology.

PY - 2021/1

Y1 - 2021/1

N2 - Background: The variability in cerebrospinal fluid (CSF) findings of myelin oligodendrocyte glycoprotein-IgG-associated disorder (MOGAD) is not fully elucidated. Objective and Methods: We retrospectively analyzed 203 attack-associated CSFs from Mayo Clinic patients (2000-2019) with MOGAD. Results: White-blood-cell (>5/mm3) elevation was less with clinically isolated optic neuritis (23%), compared to myelitis, brain/brainstem attacks, or combinations thereof (>70%), p<0.0001. CSF pleocytosis in optic neuritis was more common in patients with coexisting asymptomatic brain and/or spine MRI T2-lesions (53%) than in those without (16%), p=0.005. Abnormal CSF oligoclonal bands ranged from 1% (optic neuritis) to 18% (brain/brainstem attacks). CSF pleocytosis was less common after immunotherapy. Conclusions: CSF findings in MOGAD vary by attack phenotype and preceding treatment.

AB - Background: The variability in cerebrospinal fluid (CSF) findings of myelin oligodendrocyte glycoprotein-IgG-associated disorder (MOGAD) is not fully elucidated. Objective and Methods: We retrospectively analyzed 203 attack-associated CSFs from Mayo Clinic patients (2000-2019) with MOGAD. Results: White-blood-cell (>5/mm3) elevation was less with clinically isolated optic neuritis (23%), compared to myelitis, brain/brainstem attacks, or combinations thereof (>70%), p<0.0001. CSF pleocytosis in optic neuritis was more common in patients with coexisting asymptomatic brain and/or spine MRI T2-lesions (53%) than in those without (16%), p=0.005. Abnormal CSF oligoclonal bands ranged from 1% (optic neuritis) to 18% (brain/brainstem attacks). CSF pleocytosis was less common after immunotherapy. Conclusions: CSF findings in MOGAD vary by attack phenotype and preceding treatment.

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