Variability in the location of high frequency oscillations during prolonged intracranial EEG recordings

Stephen V. Gliske, Zachary T. Irwin, Cynthia Chestek, Garnett L. Hegeman, Benjamin Brinkmann, Oren Sagher, Hugh J.L. Garton, Gregory Alan Worrell, William C. Stacey

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The rate of interictal high frequency oscillations (HFOs) is a promising biomarker of the seizure onset zone, though little is known about its consistency over hours to days. Here we test whether the highest HFO-rate channels are consistent across different 10-min segments of EEG during sleep. An automated HFO detector and blind source separation are applied to nearly 3000 total hours of data from 121 subjects, including 12 control subjects without epilepsy. Although interictal HFOs are significantly correlated with the seizure onset zone, the precise localization is consistent in only 22% of patients. The remaining patients either have one intermittent source (16%), different sources varying over time (45%), or insufficient HFOs (17%). Multiple HFO networks are found in patients with both one and multiple seizure foci. These results indicate that robust HFO interpretation requires prolonged analysis in context with other clinical data, rather than isolated review of short data segments.

Original languageEnglish (US)
Article number2155
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

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electroencephalography
Blind source separation
Biomarkers
Electroencephalography
Seizures
recording
Detectors
oscillations
seizures
Epilepsy
Sleep
epilepsy
sleep
biomarkers
Electrocorticography
detectors

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Variability in the location of high frequency oscillations during prolonged intracranial EEG recordings. / Gliske, Stephen V.; Irwin, Zachary T.; Chestek, Cynthia; Hegeman, Garnett L.; Brinkmann, Benjamin; Sagher, Oren; Garton, Hugh J.L.; Worrell, Gregory Alan; Stacey, William C.

In: Nature Communications, Vol. 9, No. 1, 2155, 01.12.2018.

Research output: Contribution to journalArticle

Gliske, Stephen V. ; Irwin, Zachary T. ; Chestek, Cynthia ; Hegeman, Garnett L. ; Brinkmann, Benjamin ; Sagher, Oren ; Garton, Hugh J.L. ; Worrell, Gregory Alan ; Stacey, William C. / Variability in the location of high frequency oscillations during prolonged intracranial EEG recordings. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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