Varenicline for tobacco dependence treatment in recovering alcohol-dependent smokers: An open-label pilot study

J. Taylor Hays, Ivana T. Croghan, Darrell R. Schroeder, Jon O. Ebbert, Richard D. Hurt

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The purpose of this study was to obtain preliminary evidence of the efficacy of a 12-week course of varenicline for 7-day point prevalence smoking abstinence among recovering alcohol-dependent smokers. We enrolled 32 smokers with 6 months or more of recovery from alcohol dependence in an open-label clinical trial. Participants received varenicline 1 mg twice daily and 12 weeks of behavioral counseling. Participants were 69% men, 94% Caucasian, and smoking an average of 20.3 ± 5.0 cigarettes per day. After 12 weeks of treatment, 31% were biochemically confirmed 7-day point prevalence abstinent from smoking and 28% had prolonged smoking abstinence (2 weeks after target quit date onward). The most common adverse effects were mild to moderate nausea (28%) and sleep disturbance (19%). No serious adverse events were reported. Varenicline may be a useful aid for treating tobacco dependence among smokers who are in stable recovery from alcohol dependence. Further study of this treatment is warranted.

Original languageEnglish (US)
Pages (from-to)102-107
Number of pages6
JournalJournal of Substance Abuse Treatment
Volume40
Issue number1
DOIs
StatePublished - Jan 1 2011

Keywords

  • Abstinence
  • Alcohol dependence
  • Smoking cessation
  • Tobacco use disorder
  • Varenicline

ASJC Scopus subject areas

  • Phychiatric Mental Health
  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

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