VAPSE-based analysis: A two-phased candidate gene approach for elucidating genetic predisposition to complex disorders

Brian G. Weinshenker, Steve Sommer

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The extraordinary success of linkage analysis in diseases with Mendelian inheritance has not extended readily to the genetics of common complex diseases. VAPSE-based analysis is a type of candidate gene approach that represents an alternative strategy by which genetic mechanisms can be defined despite the presence of substantial genetic heterogeneity. Recent advances in mutation screening and statistical methodology have enhanced substantially the efficiency and power of this approach. The "bread and butter" of VAPSE-based analysis is genotype-to-phenotype searches in large populations with computerized medical records.

Original languageEnglish (US)
Pages (from-to)7-17
Number of pages11
JournalMutation Research - Mutation Research Genomics
Volume458
Issue number1-2
DOIs
StatePublished - Dec 1 2001

Keywords

  • Multifactorial disease
  • SNP/genetic epidemiology

ASJC Scopus subject areas

  • Toxicology
  • Genetics

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