TY - JOUR
T1 - Vancouver Hybrid
T2 - Preliminary Experience in the Treatment of Hodgkin's Disease in Childhood and Adolescence
AU - KHAN, SHAKILA P.
AU - GILCHRIST, GERALD S.
AU - ARNDT, CAROLA A.S.
AU - SMITHSON, WILLIAM A.
AU - CHEN, MICHAEL G.
AU - SCHOMBERG, PAULA J.
AU - MATSUMOTO, JANE M.S.
AU - O'FALLON, WILLIAM M.
N1 - Funding Information:
This study was supported in part by Grants CA 28882 and CA 15083 from the National Institutes of Health, Public Health Service.
PY - 1994
Y1 - 1994
N2 - To describe our preliminary experience with 19 young patients with newly diagnosed Hodgkin's disease who received the Vancouver hybrid chemotherapeutic regimen. We summarized the characteristics of our 19 study patients, the treatment administered (between June 1988 and June 1992), and the outcome. The Vancouver hybrid, which consists of mechlorethamine, vincristine sulfate (Oncovin), procarbazine hydrochloride, prednisone, doxorubicin hydrochloride (Adriamycin), bleomycin, and vinblastine sulfate (MOPP/ABV), was based on the hypothesis of preventing drug resistance by early introduction and alternation of all active agents and was aimed at decreasing the severity and frequency of treatment-related complications. Of our 19 patients with Hodgkin's disease (age range, 6 to 20 years) treated with this regimen, 2 had clinical stage I disease, 10 had stage II, 6 had stage III, and 1 had stage IV. Only two patients had systemic symptoms, and nodular sclerosis was the most common histologic feature. Patients were given four to eight cycles of chemotherapy, depending on the clinical stage of disease. In addition, 10 patients received irradiation, including 6 of 9 patients with bulky disease. In all patients, complete remission was achieved. After a median follow-up of 3.3 years, only two patients had had a relapse; both underwent autologous bone marrow transplantation and were alive and well with no evidence of disease at last follow-up. The treatment was well tolerated, and delivery of treatment was excellent. The only severe toxicity was myelosuppression; 8 patients experienced a total of 15 episodes of fever and neutropenia that necessitated hospitalization and antibiotic therapy, but no systemic infections were confirmed during 104 cycles of therapy. The MOPP/ABV hybrid is an effective and well-tolerated therapy in most young patients with Hodgkin's disease. Long-term monitoring is needed to evaluate late effects.
AB - To describe our preliminary experience with 19 young patients with newly diagnosed Hodgkin's disease who received the Vancouver hybrid chemotherapeutic regimen. We summarized the characteristics of our 19 study patients, the treatment administered (between June 1988 and June 1992), and the outcome. The Vancouver hybrid, which consists of mechlorethamine, vincristine sulfate (Oncovin), procarbazine hydrochloride, prednisone, doxorubicin hydrochloride (Adriamycin), bleomycin, and vinblastine sulfate (MOPP/ABV), was based on the hypothesis of preventing drug resistance by early introduction and alternation of all active agents and was aimed at decreasing the severity and frequency of treatment-related complications. Of our 19 patients with Hodgkin's disease (age range, 6 to 20 years) treated with this regimen, 2 had clinical stage I disease, 10 had stage II, 6 had stage III, and 1 had stage IV. Only two patients had systemic symptoms, and nodular sclerosis was the most common histologic feature. Patients were given four to eight cycles of chemotherapy, depending on the clinical stage of disease. In addition, 10 patients received irradiation, including 6 of 9 patients with bulky disease. In all patients, complete remission was achieved. After a median follow-up of 3.3 years, only two patients had had a relapse; both underwent autologous bone marrow transplantation and were alive and well with no evidence of disease at last follow-up. The treatment was well tolerated, and delivery of treatment was excellent. The only severe toxicity was myelosuppression; 8 patients experienced a total of 15 episodes of fever and neutropenia that necessitated hospitalization and antibiotic therapy, but no systemic infections were confirmed during 104 cycles of therapy. The MOPP/ABV hybrid is an effective and well-tolerated therapy in most young patients with Hodgkin's disease. Long-term monitoring is needed to evaluate late effects.
KW - ABVD
KW - CR
KW - MOPP
KW - MOPP/ABV
KW - complete remission
KW - doxorubicin hydrochloride (Adriamycin), bleomycin, vinblastine sulfate, and dacarbazine
KW - mechlorethamine, vincristine sulfate (Oncovin), procarbazine hydrochloride, and prednisone
KW - the Vancouver hybrid chemotherapeutic regimen
UR - http://www.scopus.com/inward/record.url?scp=0027967112&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027967112&partnerID=8YFLogxK
U2 - 10.1016/S0025-6196(12)61818-7
DO - 10.1016/S0025-6196(12)61818-7
M3 - Article
C2 - 7523802
AN - SCOPUS:0027967112
SN - 0025-6196
VL - 69
SP - 949
EP - 954
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 10
ER -