Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients with Recurrent Clostridium difficile Infection

Roberto L. Patron, Carlos A. Hartmann, Sorcha Allen, Cheryl L. Griesbach, Heidi E. Kosiorek, John K. Dibaise, Robert Orenstein

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We retrospectively analyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determine risk factors for FMT failure. In a multivariate analysis, failure to use an oral vancomycin taper preceding FMT was associated with a significant risk of FMT failure (odds ratio, 0.15; 95% confidence interval,.007-.40).

Original languageEnglish (US)
Pages (from-to)1214-1217
Number of pages4
JournalClinical Infectious Diseases
Volume65
Issue number7
DOIs
StatePublished - Oct 1 2017

Keywords

  • Clostridium difficile
  • fecal microbiota transplantation
  • FMT failure
  • tapered oral vancomycin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Patron, R. L., Hartmann, C. A., Allen, S., Griesbach, C. L., Kosiorek, H. E., Dibaise, J. K., & Orenstein, R. (2017). Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients with Recurrent Clostridium difficile Infection. Clinical Infectious Diseases, 65(7), 1214-1217. https://doi.org/10.1093/cid/cix511