Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients with Recurrent Clostridium difficile Infection

Roberto L. Patron; Carlos A. Hartmann; Sorcha Allen; Cheryl L. Griesbach; Heidi E. Kosiorek; John K. Dibaise; Robert Orenstein

doi:10.1093/cid/cix511

Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients with Recurrent Clostridium difficile Infection

Roberto L. Patron, Carlos A. Hartmann, Sorcha Allen, Cheryl L. Griesbach, Heidi E. Kosiorek, John K. Dibaise, Robert Orenstein

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We retrospectively analyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determine risk factors for FMT failure. In a multivariate analysis, failure to use an oral vancomycin taper preceding FMT was associated with a significant risk of FMT failure (odds ratio, 0.15; 95% confidence interval,.007-.40).

Original language	English (US)
Pages (from-to)	1214-1217
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	65
Issue number	7
DOIs	https://doi.org/10.1093/cid/cix511
State	Published - Oct 1 2017

Keywords

Clostridium difficile
FMT failure
fecal microbiota transplantation
tapered oral vancomycin

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1093/cid/cix511

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title = "Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients with Recurrent Clostridium difficile Infection",

abstract = "We retrospectively analyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determine risk factors for FMT failure. In a multivariate analysis, failure to use an oral vancomycin taper preceding FMT was associated with a significant risk of FMT failure (odds ratio, 0.15; 95% confidence interval,.007-.40).",

keywords = "Clostridium difficile, FMT failure, fecal microbiota transplantation, tapered oral vancomycin",

author = "Patron, {Roberto L.} and Hartmann, {Carlos A.} and Sorcha Allen and Griesbach, {Cheryl L.} and Kosiorek, {Heidi E.} and Dibaise, {John K.} and Robert Orenstein",

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AU - Patron, Roberto L.

AU - Hartmann, Carlos A.

AU - Allen, Sorcha

AU - Griesbach, Cheryl L.

AU - Kosiorek, Heidi E.

AU - Dibaise, John K.

AU - Orenstein, Robert

PY - 2017/10/1

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N2 - We retrospectively analyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determine risk factors for FMT failure. In a multivariate analysis, failure to use an oral vancomycin taper preceding FMT was associated with a significant risk of FMT failure (odds ratio, 0.15; 95% confidence interval,.007-.40).

AB - We retrospectively analyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determine risk factors for FMT failure. In a multivariate analysis, failure to use an oral vancomycin taper preceding FMT was associated with a significant risk of FMT failure (odds ratio, 0.15; 95% confidence interval,.007-.40).

KW - Clostridium difficile

KW - FMT failure

KW - fecal microbiota transplantation

KW - tapered oral vancomycin

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Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients with Recurrent Clostridium difficile Infection

Abstract

Keywords

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