Valvular heart disease with the use of fenfluramine-phentermine

Phani Surapaneni; Karyne L. Vinales; Mohammad Q. Najib; Hari P. Chaliki

Valvular heart disease with the use of fenfluramine-phentermine

Phani Surapaneni, Karyne L. Vinales, Mohammad Q. Najib, Hari P. Chaliki

Cardiovascular Diseases

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Exposure to the anorectic drug fenfluramine, alone or in combination with phentermine, a noradrenergic central nervous system stimulant, has been associated with unusual cardiac valvular morphology and resultant regurgitation of the left- and right-sided heart valves. The prevalence of significant valvular disease associated with the use of these anorectic drugs is reported to be as high as 23%. Herein, we report the occurrence of multivalvular disease and pulmonary hypertension associated with fenfluramine-phentermine use, discovered in an obese 59-year-old woman before expected gastric bypass surgery.

Original language	English (US)
Pages (from-to)	581-583
Number of pages	3
Journal	Texas Heart Institute Journal
Volume	38
Issue number	5
State	Published - 2011

Keywords

Aortic valve insufficiency/chemically induced
Appetite depressants/adverse effects
Fenfluramine/adverse effects
Heart valve diseases/chemically induced/complications/pathology
Hypertension
Mitral valve insufficiency/chemically induced
Obesity/complications
Phentermine/adverse effects
Pulmonary/chemically induced
Treatment outcome
Tricuspid valve insufficiency/chemically induced

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Cite this

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title = "Valvular heart disease with the use of fenfluramine-phentermine",

abstract = "Exposure to the anorectic drug fenfluramine, alone or in combination with phentermine, a noradrenergic central nervous system stimulant, has been associated with unusual cardiac valvular morphology and resultant regurgitation of the left- and right-sided heart valves. The prevalence of significant valvular disease associated with the use of these anorectic drugs is reported to be as high as 23%. Herein, we report the occurrence of multivalvular disease and pulmonary hypertension associated with fenfluramine-phentermine use, discovered in an obese 59-year-old woman before expected gastric bypass surgery.",

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AU - Surapaneni, Phani

AU - Vinales, Karyne L.

AU - Najib, Mohammad Q.

AU - Chaliki, Hari P.

PY - 2011

Y1 - 2011

N2 - Exposure to the anorectic drug fenfluramine, alone or in combination with phentermine, a noradrenergic central nervous system stimulant, has been associated with unusual cardiac valvular morphology and resultant regurgitation of the left- and right-sided heart valves. The prevalence of significant valvular disease associated with the use of these anorectic drugs is reported to be as high as 23%. Herein, we report the occurrence of multivalvular disease and pulmonary hypertension associated with fenfluramine-phentermine use, discovered in an obese 59-year-old woman before expected gastric bypass surgery.

AB - Exposure to the anorectic drug fenfluramine, alone or in combination with phentermine, a noradrenergic central nervous system stimulant, has been associated with unusual cardiac valvular morphology and resultant regurgitation of the left- and right-sided heart valves. The prevalence of significant valvular disease associated with the use of these anorectic drugs is reported to be as high as 23%. Herein, we report the occurrence of multivalvular disease and pulmonary hypertension associated with fenfluramine-phentermine use, discovered in an obese 59-year-old woman before expected gastric bypass surgery.

KW - Aortic valve insufficiency/chemically induced

KW - Appetite depressants/adverse effects

KW - Fenfluramine/adverse effects

KW - Heart valve diseases/chemically induced/complications/pathology

KW - Hypertension

KW - Mitral valve insufficiency/chemically induced

KW - Obesity/complications

KW - Phentermine/adverse effects

KW - Pulmonary/chemically induced

KW - Treatment outcome

KW - Tricuspid valve insufficiency/chemically induced

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Valvular heart disease with the use of fenfluramine-phentermine

Abstract

Keywords

ASJC Scopus subject areas

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