Valvular Heart Disease: New Concepts in Pathophysiology and Therapeutic Approaches

Mackram F. Eleid, Vuyisile T. Nkomo, Sorin V. Pislaru, Bernard J. Gersh

Research output: Contribution to journalReview articlepeer-review


This review discusses recent advancements in the field of valvular heart disease. Topics covered include recognition of the impact of atrial fibrillation on development and assessment of valvular disease, strategies for global prevention of rheumatic heart disease, understanding and management of secondary mitral regurgitation, the updated classification of bicuspid aortic valve disease, recognition of heightened cardiovascular risk associated with moderate aortic stenosis, and a growing armamentarium of transcatheter therapies.

Original languageEnglish (US)
Pages (from-to)155-170
Number of pages16
JournalAnnual Review of Medicine
StatePublished - Jan 27 2023


  • aortic stenosis
  • bicuspid aortic valve disease
  • mitral regurgitation
  • mitral stenosis
  • rheumatic heart disease
  • tricuspid regurgitation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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