Valvular Heart Disease: New Concepts in Pathophysiology and Therapeutic Approaches

Mackram F. Eleid; Vuyisile T. Nkomo; Sorin V. Pislaru; Bernard J. Gersh

doi:10.1146/annurev-med-042921-122533

Valvular Heart Disease: New Concepts in Pathophysiology and Therapeutic Approaches

Mackram F. Eleid, Vuyisile T. Nkomo, Sorin V. Pislaru, Bernard J. Gersh

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

This review discusses recent advancements in the field of valvular heart disease. Topics covered include recognition of the impact of atrial fibrillation on development and assessment of valvular disease, strategies for global prevention of rheumatic heart disease, understanding and management of secondary mitral regurgitation, the updated classification of bicuspid aortic valve disease, recognition of heightened cardiovascular risk associated with moderate aortic stenosis, and a growing armamentarium of transcatheter therapies.

Original language	English (US)
Pages (from-to)	155-170
Number of pages	16
Journal	Annual Review of Medicine
Volume	74
DOIs	https://doi.org/10.1146/annurev-med-042921-122533
State	Published - Jan 27 2023

Keywords

aortic stenosis
bicuspid aortic valve disease
mitral regurgitation
mitral stenosis
rheumatic heart disease
tricuspid regurgitation

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1146/annurev-med-042921-122533

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title = "Valvular Heart Disease: New Concepts in Pathophysiology and Therapeutic Approaches",

abstract = "This review discusses recent advancements in the field of valvular heart disease. Topics covered include recognition of the impact of atrial fibrillation on development and assessment of valvular disease, strategies for global prevention of rheumatic heart disease, understanding and management of secondary mitral regurgitation, the updated classification of bicuspid aortic valve disease, recognition of heightened cardiovascular risk associated with moderate aortic stenosis, and a growing armamentarium of transcatheter therapies.",

keywords = "aortic stenosis, bicuspid aortic valve disease, mitral regurgitation, mitral stenosis, rheumatic heart disease, tricuspid regurgitation",

author = "Eleid, {Mackram F.} and Nkomo, {Vuyisile T.} and Pislaru, {Sorin V.} and Gersh, {Bernard J.}",

year = "2023",

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doi = "10.1146/annurev-med-042921-122533",

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T2 - New Concepts in Pathophysiology and Therapeutic Approaches

AU - Eleid, Mackram F.

AU - Nkomo, Vuyisile T.

AU - Pislaru, Sorin V.

AU - Gersh, Bernard J.

PY - 2023/1/27

Y1 - 2023/1/27

N2 - This review discusses recent advancements in the field of valvular heart disease. Topics covered include recognition of the impact of atrial fibrillation on development and assessment of valvular disease, strategies for global prevention of rheumatic heart disease, understanding and management of secondary mitral regurgitation, the updated classification of bicuspid aortic valve disease, recognition of heightened cardiovascular risk associated with moderate aortic stenosis, and a growing armamentarium of transcatheter therapies.

AB - This review discusses recent advancements in the field of valvular heart disease. Topics covered include recognition of the impact of atrial fibrillation on development and assessment of valvular disease, strategies for global prevention of rheumatic heart disease, understanding and management of secondary mitral regurgitation, the updated classification of bicuspid aortic valve disease, recognition of heightened cardiovascular risk associated with moderate aortic stenosis, and a growing armamentarium of transcatheter therapies.

KW - aortic stenosis

KW - bicuspid aortic valve disease

KW - mitral regurgitation

KW - mitral stenosis

KW - rheumatic heart disease

KW - tricuspid regurgitation

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DO - 10.1146/annurev-med-042921-122533

M3 - Review article

C2 - 36400067

AN - SCOPUS:85147089609

SN - 0066-4219

VL - 74

SP - 155

EP - 170

JO - Annual Review of Medicine

JF - Annual Review of Medicine

ER -

Valvular Heart Disease: New Concepts in Pathophysiology and Therapeutic Approaches

Abstract

Keywords

ASJC Scopus subject areas

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