Valvular heart disease in patients taking pergolide

Allison M. Pritchett, John F. Morrison, William D. Edwards, Hartzell V Schaff, Heidi M. Connolly, Raul Emilio Espinosa

Research output: Contribution to journalArticle

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Abstract

Objective: To determine whether an association exists between pergolide and valvular heart disease. Patients and Methods: Three patients with severe, unexplained tricuspid regurgitation were examined at our institution from September 2000 to April 2002. Echocardiography and histology of surgically explanted valves revealed abnormalities suggestive of carcinoid involvement, methysergide or ergotamine treatment, or use of fenfluramine and dexfenfluramine. Carcinoid valvular heart disease was excluded. None of the patients had prior treatment with these drugs. All 3 patients were taking pergolide. Results: Of the 3 patients, 2 had predominantly right-sided congestive heart failure. In all 3 patients, echocardiography showed unusual valve morphology, with severe tricuspid valve regurgitation. Significant left-sided valve regurgitation was noted in 2 patients. Histologic analysis revealed surface fibroproliferative lesions with preserved underlying valve architecture. Conclusion: The echocardiographic and histopathologic features of these cases are strikingly similar to those associated with carcinoid-, ergot-, and fenfluramine-induced valve disease. An association between pergolide and valvular heart disease may therefore exist.

Original languageEnglish (US)
Pages (from-to)1280-1286
Number of pages7
JournalMayo Clinic Proceedings
Volume77
Issue number12
StatePublished - Dec 1 2002

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Pergolide
Heart Valve Diseases
Fenfluramine
Tricuspid Valve Insufficiency
Carcinoid Tumor
Echocardiography
Carcinoid Heart Disease
Heart Failure
Dexfenfluramine
Ergotamine
Methysergide
Histology
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pritchett, A. M., Morrison, J. F., Edwards, W. D., Schaff, H. V., Connolly, H. M., & Espinosa, R. E. (2002). Valvular heart disease in patients taking pergolide. Mayo Clinic Proceedings, 77(12), 1280-1286.

Valvular heart disease in patients taking pergolide. / Pritchett, Allison M.; Morrison, John F.; Edwards, William D.; Schaff, Hartzell V; Connolly, Heidi M.; Espinosa, Raul Emilio.

In: Mayo Clinic Proceedings, Vol. 77, No. 12, 01.12.2002, p. 1280-1286.

Research output: Contribution to journalArticle

Pritchett, AM, Morrison, JF, Edwards, WD, Schaff, HV, Connolly, HM & Espinosa, RE 2002, 'Valvular heart disease in patients taking pergolide', Mayo Clinic Proceedings, vol. 77, no. 12, pp. 1280-1286.
Pritchett AM, Morrison JF, Edwards WD, Schaff HV, Connolly HM, Espinosa RE. Valvular heart disease in patients taking pergolide. Mayo Clinic Proceedings. 2002 Dec 1;77(12):1280-1286.
Pritchett, Allison M. ; Morrison, John F. ; Edwards, William D. ; Schaff, Hartzell V ; Connolly, Heidi M. ; Espinosa, Raul Emilio. / Valvular heart disease in patients taking pergolide. In: Mayo Clinic Proceedings. 2002 ; Vol. 77, No. 12. pp. 1280-1286.
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