Validity of composite end points in clinical trials

Victor Manuel Montori, Gaietà Permanyer-Miralda, Ignacio Ferreira-González, Jason W. Busse, Valeria Pacheco-Huergo, Dianne Bryant, Jordi Alonso, Elie A. Akl, Antònia Domingo-Salvany, Edward Mills, Ping Wu, Holger J. Schünemann, Roman Jaeschke, Gordon H. Guyatt

Research output: Contribution to journalArticle

257 Citations (Scopus)

Abstract

Use of composite end points as the main outcome in randomised trials can hide wide differences in the individual measures. How should you apply the results to clinical practice?

Original languageEnglish (US)
Pages (from-to)594-596
Number of pages3
JournalBritish Medical Journal
Volume330
Issue number7491
StatePublished - Mar 12 2005

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Individuality
Clinical Trials

ASJC Scopus subject areas

  • Medicine(all)

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Montori, V. M., Permanyer-Miralda, G., Ferreira-González, I., Busse, J. W., Pacheco-Huergo, V., Bryant, D., ... Guyatt, G. H. (2005). Validity of composite end points in clinical trials. British Medical Journal, 330(7491), 594-596.

Validity of composite end points in clinical trials. / Montori, Victor Manuel; Permanyer-Miralda, Gaietà; Ferreira-González, Ignacio; Busse, Jason W.; Pacheco-Huergo, Valeria; Bryant, Dianne; Alonso, Jordi; Akl, Elie A.; Domingo-Salvany, Antònia; Mills, Edward; Wu, Ping; Schünemann, Holger J.; Jaeschke, Roman; Guyatt, Gordon H.

In: British Medical Journal, Vol. 330, No. 7491, 12.03.2005, p. 594-596.

Research output: Contribution to journalArticle

Montori, VM, Permanyer-Miralda, G, Ferreira-González, I, Busse, JW, Pacheco-Huergo, V, Bryant, D, Alonso, J, Akl, EA, Domingo-Salvany, A, Mills, E, Wu, P, Schünemann, HJ, Jaeschke, R & Guyatt, GH 2005, 'Validity of composite end points in clinical trials', British Medical Journal, vol. 330, no. 7491, pp. 594-596.
Montori VM, Permanyer-Miralda G, Ferreira-González I, Busse JW, Pacheco-Huergo V, Bryant D et al. Validity of composite end points in clinical trials. British Medical Journal. 2005 Mar 12;330(7491):594-596.
Montori, Victor Manuel ; Permanyer-Miralda, Gaietà ; Ferreira-González, Ignacio ; Busse, Jason W. ; Pacheco-Huergo, Valeria ; Bryant, Dianne ; Alonso, Jordi ; Akl, Elie A. ; Domingo-Salvany, Antònia ; Mills, Edward ; Wu, Ping ; Schünemann, Holger J. ; Jaeschke, Roman ; Guyatt, Gordon H. / Validity of composite end points in clinical trials. In: British Medical Journal. 2005 ; Vol. 330, No. 7491. pp. 594-596.
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