Validity and sensitivity of an intravenous bile acid tolerance test in patients with liver disease

Nicholas F La Russo, N. E. Hoffman, A. F. Hofmann, M. G. Korman

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

A bile acid tolerance test, which measures the plasma disappearance rate of injected cholylglycine by radioimmunoassay, was studied in 36 patients with biopsy proved chronic liver disease and compared to fasting state levels of conjugated cholic acid and other conventional liver tests. In 25 patients in whom one or more of the conventional tests for liver disease showed abnormal results, fasting state levels of conjugated cholic acid were increased in 20, but plasma disappearance of cholylglycine was delayed in all. Of the 11 other patients in whom conventional tests were within normal limits, fasting state levels of conjugated cholic acid were increased in 3 of 10, but cholylglycine disappearance was delayed in 9 of 11. The bile acid tolerance test indicated liver disease more sensitively than the fasting state level of conjugated cholic acid, which, in turn, was more sensitive than other conventional liver tests.

Original languageEnglish (US)
Pages (from-to)1209-1214
Number of pages6
JournalNew England Journal of Medicine
Volume292
Issue number23
StatePublished - 1975

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Cholic Acid
Glycocholic Acid
Bile Acids and Salts
Liver Diseases
Fasting
Liver
Radioimmunoassay
Chronic Disease
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Validity and sensitivity of an intravenous bile acid tolerance test in patients with liver disease. / La Russo, Nicholas F; Hoffman, N. E.; Hofmann, A. F.; Korman, M. G.

In: New England Journal of Medicine, Vol. 292, No. 23, 1975, p. 1209-1214.

Research output: Contribution to journalArticle

La Russo, Nicholas F ; Hoffman, N. E. ; Hofmann, A. F. ; Korman, M. G. / Validity and sensitivity of an intravenous bile acid tolerance test in patients with liver disease. In: New England Journal of Medicine. 1975 ; Vol. 292, No. 23. pp. 1209-1214.
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