Abstract
Background: The telephone assessment of cognitive functions may reduce the cost and burden of epidemiological studies. Methods: We validated the Telephone Interview for Cognitive Status-modified (TICS-m) using an extensive in-person assessment as the standard for comparison. Clinical diagnoses of normal cognition, mild cognitive impairment (MCI), or dementia were established by consensus of physician, nurse, and neuropsychological assessments. Results: The extensive in-person assessment classified 83 persons with normal cognition, 42 persons with MCI, and 42 persons with dementia. There was considerable overlap in TICS-m scores among the three groups. Receiver operating characteristic curves identified ≤31 as the optimal cutoff score to separate subjects with MCI from subjects with normal cognition (sensitivity = 71.4%; subjects with dementia excluded), and ≤27 to separate subjects with dementia from subjects with MCI (sensitivity = 69.0%; subjects with normal cognition excluded). The TICS-m performed well when subjects with MCI were pooled either with subjects with dementia (sensitivity = 83.3%) or with subjects with normal cognition (sensitivity = 83.3%). Conclusions: Although the TICS-m performed well when using a dichotomous classification of cognitive status, it performed only fairly in separating MCI from either normal cognition or dementia. The TICS-m should not be used as a free-standing tool to identify subjects with MCI, and it should be used with caution as a tool to detect dementia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 34-42 |
| Number of pages | 9 |
| Journal | Neuroepidemiology |
| Volume | 34 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2010 |
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Keywords
- Dementia
- Mild cognitive impairment
- Telephone Interview for Cognitive Status-modified
ASJC Scopus subject areas
- Epidemiology
- Clinical Neurology
Cite this
Validation of the telephone interview for cognitive status-modified in subjects with normal cognition, mild cognitive impairment, or dementia. / Knopman, David S; Roberts, Rosebud O; Geda, Yonas Endale; Pankratz, V. Shane; Christianson, Teresa J H; Petersen, Ronald Carl; Rocca, Walter A.
In: Neuroepidemiology, Vol. 34, No. 1, 01.2010, p. 34-42.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Validation of the telephone interview for cognitive status-modified in subjects with normal cognition, mild cognitive impairment, or dementia
AU - Knopman, David S
AU - Roberts, Rosebud O
AU - Geda, Yonas Endale
AU - Pankratz, V. Shane
AU - Christianson, Teresa J H
AU - Petersen, Ronald Carl
AU - Rocca, Walter A
PY - 2010/1
Y1 - 2010/1
N2 - Background: The telephone assessment of cognitive functions may reduce the cost and burden of epidemiological studies. Methods: We validated the Telephone Interview for Cognitive Status-modified (TICS-m) using an extensive in-person assessment as the standard for comparison. Clinical diagnoses of normal cognition, mild cognitive impairment (MCI), or dementia were established by consensus of physician, nurse, and neuropsychological assessments. Results: The extensive in-person assessment classified 83 persons with normal cognition, 42 persons with MCI, and 42 persons with dementia. There was considerable overlap in TICS-m scores among the three groups. Receiver operating characteristic curves identified ≤31 as the optimal cutoff score to separate subjects with MCI from subjects with normal cognition (sensitivity = 71.4%; subjects with dementia excluded), and ≤27 to separate subjects with dementia from subjects with MCI (sensitivity = 69.0%; subjects with normal cognition excluded). The TICS-m performed well when subjects with MCI were pooled either with subjects with dementia (sensitivity = 83.3%) or with subjects with normal cognition (sensitivity = 83.3%). Conclusions: Although the TICS-m performed well when using a dichotomous classification of cognitive status, it performed only fairly in separating MCI from either normal cognition or dementia. The TICS-m should not be used as a free-standing tool to identify subjects with MCI, and it should be used with caution as a tool to detect dementia.
AB - Background: The telephone assessment of cognitive functions may reduce the cost and burden of epidemiological studies. Methods: We validated the Telephone Interview for Cognitive Status-modified (TICS-m) using an extensive in-person assessment as the standard for comparison. Clinical diagnoses of normal cognition, mild cognitive impairment (MCI), or dementia were established by consensus of physician, nurse, and neuropsychological assessments. Results: The extensive in-person assessment classified 83 persons with normal cognition, 42 persons with MCI, and 42 persons with dementia. There was considerable overlap in TICS-m scores among the three groups. Receiver operating characteristic curves identified ≤31 as the optimal cutoff score to separate subjects with MCI from subjects with normal cognition (sensitivity = 71.4%; subjects with dementia excluded), and ≤27 to separate subjects with dementia from subjects with MCI (sensitivity = 69.0%; subjects with normal cognition excluded). The TICS-m performed well when subjects with MCI were pooled either with subjects with dementia (sensitivity = 83.3%) or with subjects with normal cognition (sensitivity = 83.3%). Conclusions: Although the TICS-m performed well when using a dichotomous classification of cognitive status, it performed only fairly in separating MCI from either normal cognition or dementia. The TICS-m should not be used as a free-standing tool to identify subjects with MCI, and it should be used with caution as a tool to detect dementia.
KW - Dementia
KW - Mild cognitive impairment
KW - Telephone Interview for Cognitive Status-modified
UR - http://www.scopus.com/inward/record.url?scp=70350665987&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350665987&partnerID=8YFLogxK
U2 - 10.1159/000255464
DO - 10.1159/000255464
M3 - Article
C2 - 19893327
AN - SCOPUS:70350665987
VL - 34
SP - 34
EP - 42
JO - Neuroepidemiology
JF - Neuroepidemiology
SN - 0251-5350
IS - 1
ER -