Validation of a bowel function diary for assessing opioid-induced constipation

Michael Camilleri, Margaret Rothman, Kai Fai Ho, Mila Etropolski

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives:Validated tools to assess opioid-induced constipation (OIC) are needed. The aim of this study was to validate a Bowel Function Diary (BF-Diary) that includes patient-reported outcomes (PROs) associated with OIC.Methods:In a multicenter, observational study, opioid-naive or recently untreated (14 days) adults with nonmalignant, chronic pain who were prescribed oral opioid and usual care completed an electronic diary daily for 2 weeks. Test-retest reliability was assessed. Validity was evaluated for two composite end pointsnumber of spontaneous bowel movements (SBM) and complete SBMs (SCBM)and for other relevant PROs.Results:Of 238 patients (mean age 54 years, 58% women), 63% reported constipation. The intraclass correlation coefficient for numbers of SBM and SCBM, and other BF-Diary PROs was 0.71 for all items except stool consistency. Mean (s.d.) number of SBM per week was significantly less in each week for patients with vs. without constipation (5.64.3 and 7.33.6, respectively over week 1, P=0.0012; similarly, P

Original languageEnglish (US)
Pages (from-to)497-506
Number of pages10
JournalAmerican Journal of Gastroenterology
Volume106
Issue number3
DOIs
StatePublished - Mar 2011

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Constipation
Opioid Analgesics
Reproducibility of Results
Chronic Pain
Multicenter Studies
Observational Studies
Patient Reported Outcome Measures

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Validation of a bowel function diary for assessing opioid-induced constipation. / Camilleri, Michael; Rothman, Margaret; Ho, Kai Fai; Etropolski, Mila.

In: American Journal of Gastroenterology, Vol. 106, No. 3, 03.2011, p. 497-506.

Research output: Contribution to journalArticle

Camilleri, Michael ; Rothman, Margaret ; Ho, Kai Fai ; Etropolski, Mila. / Validation of a bowel function diary for assessing opioid-induced constipation. In: American Journal of Gastroenterology. 2011 ; Vol. 106, No. 3. pp. 497-506.
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