Vagus nerve stimulation for epilepsy: Randomized comparison of three stimulation paradigms

Christopher DeGiorgio, C. Heck, S. Bunch, J. Britton, P. Green, M. Lancman, J. Murphy, P. Olejniczak, J. Shih, S. Arrambide, J. Soss

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Vagus nerve stimulation (VNS) is an effective adjunctive treatment for intractable epilepsy. However, the optimal range of device duty-cycles [on/ (on + off times)] is poorly understood. The authors performed a multicenter, randomized trial of three unique modes of VNS, which varied primarily by duty-cycle. The results indicate that the three duty-cycles were equally effective. The data support the use of standard duty-cycles as initial therapy.

Original languageEnglish (US)
Pages (from-to)317-319
Number of pages3
JournalNeurology
Volume65
Issue number2
DOIs
StatePublished - Jul 26 2005

ASJC Scopus subject areas

  • Clinical Neurology

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    DeGiorgio, C., Heck, C., Bunch, S., Britton, J., Green, P., Lancman, M., Murphy, J., Olejniczak, P., Shih, J., Arrambide, S., & Soss, J. (2005). Vagus nerve stimulation for epilepsy: Randomized comparison of three stimulation paradigms. Neurology, 65(2), 317-319. https://doi.org/10.1212/01.wnl.0000168899.11598.00