Vaccinomics and personalized vaccinology: Is science leading us toward a new path of directed vaccine development and discovery?

Gregory A. Poland, Richard B. Kennedy, Inna G. Ovsyannikova

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

As is apparent in many fields of science and medicine, the new biology, and particularly new high-throughput genetic sequencing and transcriptomic and epigenetic technologies, are radically altering our understanding and views of science. In this article, we make the case that while mostly ignored thus far in the vaccine field, these changes will revolutionize vaccinology from development to manufacture to administration. Such advances will address a current major barrier in vaccinology-that of empiric vaccine discovery and development, and the subsequent low yield of viable vaccine candidates, particularly for hyper-variable viruses. While our laboratory's data and thinking (and hence also for this paper) has been directed toward viruses and viral vaccines, generalization to other pathogens and disease entities (i.e., anti-cancer vaccines) may be appropriate.

Original languageEnglish (US)
Article numbere1002344
JournalPLoS pathogens
Volume7
Issue number12
DOIs
StatePublished - Dec 1 2011

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Molecular Biology
  • Genetics
  • Virology

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