Vaccine immunogenetics: Bedside to bench to population

Gregory A. Poland, Inna G. Ovsyannikova, Robert M. Jacobson

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

The immunogenetic basis for variations in immune response to vaccines in humans remains largely unknown. Many factors can contribute to the heterogeneity of vaccine-induced immune responses, including polymorphisms of immune response genes. It is important to identify those genes involved directly or indirectly in the generation of the immune response to vaccines. Our previous work with measles reveals the impact of immune response gene polymorphisms on measles vaccine-induced humoral and cellular immune responses. We demonstrate associations between genetic variations (single nucleotide polymorphisms, SNPs) in HLA class I and class II genes, cytokine, cell surface receptor, and toll-like receptor genes and variations in immune responses to measles vaccine. Such information may provide further understanding of genetic restrictions that influence the generation of protective immune responses to vaccines, and eventually the development of new vaccines.

Original languageEnglish (US)
Pages (from-to)6183-6188
Number of pages6
JournalVaccine
Volume26
Issue number49
DOIs
StatePublished - Nov 18 2008

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Keywords

  • CD46
  • Cytokines
  • Genetic association
  • HLA
  • Measles vaccine
  • Polymorphisms
  • SLAM
  • TLR

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Poland, G. A., Ovsyannikova, I. G., & Jacobson, R. M. (2008). Vaccine immunogenetics: Bedside to bench to population. Vaccine, 26(49), 6183-6188. https://doi.org/10.1016/j.vaccine.2008.06.057