UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survival

Dominik Peus, Remus A. Vasa, Alexander Meves, Astrid Beyerle, Mark R. Pittelkow

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

We have recently shown that UVB radiation activates epidermal growth factor receptor (EGFR)/extracellular regulated kinase 1 and 2 (ERK1/2) and p38 signaling pathways in keratinocytes. However, the functional relevance of these processes for downstream signaling and cell survival remains to be determined. The specific EGFR inhibitor PD153035 markedly decreased UVB-induced phosphorylation of EGFR, ERK1/2 and shc, whereas p38 activation was unaffected. PD153035 pretreatment followed by UVB reduced clonogenic potential and enhanced peroxide production, apoptosis and cell death. Our data suggest that ligand-independent phosphorylation of EGFR and likely dependent downstream signaling pathways regulate cellular defense mechanisms important for cell survival following oxidative stress.

Original languageEnglish (US)
Pages (from-to)135-140
Number of pages6
JournalPhotochemistry and Photobiology
Volume72
Issue number1
DOIs
StatePublished - Jul 1 2000

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry

Fingerprint Dive into the research topics of 'UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survival'. Together they form a unique fingerprint.

Cite this