Utilization of dietary precursors for carnitine synthesis in human adults

C. J. Rebouche, E. P. Bosch, C. A. Chenard, K. J. Schabold, S. E. Nelson

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Endogenous synthetic pathways are presumed to be sufficient to provide adequate amounts of carnitine to meet the needs of the body. However, circulating carnitine levels of strict vegetarian adults and children, and particularly of infants fed carnitine-free formulas, are significantly lower than normal. Therefore, we investigated loci at which rates of carnitine synthesis may be restricted in human adults. Excess amounts of the carnitine precursors lysine plus methionine, ε-N-trimethyllysine or γ-butyrobetaine were fed as supplements to a low carnitine diet for 10 d. Rate of carnitine synthesis was estimated by changes in carnitine excretion and changes in serum and muscle carnitine levels. Dietary γ-butyrobetaine dramatically increased carnitine production, ε-N-trimethyllysine had a somewhat smaller effect, and lysine plus methionine had even less effect on carnitine synthesis. We conclude that carnitine synthesis is not limited by the activity of γ-butyrobetaine hydroxylase. Carnitine synthesis from exogenous ε-N-trimethyllysine is limited either by enzymatic processes that lead to the final intermediate, γ-butyrobetaine, or by the ability of this substrate to enter tissues capable of carrying out these transformations.

Original languageEnglish (US)
Pages (from-to)1907-1913
Number of pages7
JournalJournal of Nutrition
Volume119
Issue number12
DOIs
StatePublished - Jan 1 1989

Keywords

  • L- methionine
  • L-carnitine biosynthesis
  • L-lysine
  • adult humans
  • metabolic regulation
  • γ-butyrobetaine
  • ε-N-trimethyl-L-lysine

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Rebouche, C. J., Bosch, E. P., Chenard, C. A., Schabold, K. J., & Nelson, S. E. (1989). Utilization of dietary precursors for carnitine synthesis in human adults. Journal of Nutrition, 119(12), 1907-1913. https://doi.org/10.1093/jn/119.12.1907