Utilization of a Genomic Classifier for Prediction of Metastasis Following Salvage Radiation Therapy after Radical Prostatectomy

Stephen J. Freedland, Voleak Choeurng, Lauren Howard, Amanda De Hoedt, Marguerite du Plessis, Kasra Yousefi, Lucia L. Lam, Christine Buerki, Seong Ra, Bruce Robbins, Edouard J. Trabulsi, Nikhil L. Shah, Firas Abdollah, Felix Y. Feng, Elai Davicioni, Adam P. Dicker, Robert Jeffrey Karnes, Robert B. Den

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Background: Despite salvage radiation therapy (SRT) for recurrent prostate cancer (PCa) after radical prostatectomy (RP), some patients still progress to metastases. Identifying these men would allow them to undergo systemic therapy including testing novel therapies to reduce metastases risk. Objective: To test whether the genomic classifier (GC) predicts development of metastatic disease. Design, setting, and participants: Retrospective multi-center and multi-ethnic cohort study from two academic centers and one Veterans Affairs Medical Center in the United States involving 170 men receiving SRT for recurrent PCa post-RP. Outcome measurements and statistical analysis: Time from SRT to development of metastatic disease tested using Cox regression, survival c-index, and decision curve analysis. Performance of GC was compared to the Cancer of the Prostate Risk Assessment Score and Briganti risk models based on these metrics. Results and limitations: With a median 5.7 yr follow-up after SRT, 20 patients (12%) developed metastases. On multivariable analysis, for each 0.1 unit increase in GC (scaled from 0 to 1), the hazard ratio for metastasis was 1.58 (95% confidence interval 1.16-2.17; p = 0.002). Adjusting for androgen deprivation therapy did not materially change the results. The c-index for GC was 0.85 (95% confidence interval 0.73-0.88) versus 0.63-0.65 for published clinico-pathologic risk models. The 5-yr cumulative incidence of metastasis post-SRT in patients with low, intermediate, and high GC scores was 2.7%, 8.4%, and 33.1%, respectively (p

Original languageEnglish (US)
JournalEuropean Urology
DOIs
StateAccepted/In press - 2016

Keywords

  • Genomic classifier
  • Metastasis
  • Prognosis
  • Prostate cancer
  • Salvage radiation therapy

ASJC Scopus subject areas

  • Urology

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